Reardon, Sara. “Phage Therapy Gets Revitalized.” Nature 510, no. 7503 (June 4, 2014). https://www.nature.com/news/phage-therapy-gets-revitalized-1.15348.
Summers, W. C. “Bacteriophage Therapy.” Annual Review of Microbiology 55 (2001): 437–451.
Summers, W. C. “Félix Hubert d’Hérelle (1873–1949): History of a Scientific Mind.” Bacteriophage 6, no. 4 (2016): e1270090.
Chapter 18. Panning for Gold
Henry, M., B. Biswas, L. Vincent, V. Mokashi, R. Schuch, K. A. Bishop-Lilly, and S. Sozhamannan. “Development of a High Throughput Assay for Indirectly Measuring Phage Growth Using the Omnilog™ System.” Bacteriophage 2, no. 3 (July 1, 2012): 159–167.
Kutter, E. M., S. J. Kuhl, and S. T. Abedon. “Re-Establishing a Place for Phage Therapy in Western Medicine.” Future Microbiology 10, no. 5 (2015): 685–688.
Merril, C. R., D. Scholl, and S. L. Adhya. “The Prospect for Bacteriophage Therapy in Western Medicine.” National Review of Drug Discovery 2, no. 6 (Jun 2003): 489–497.
Pirnay, J. P., D. De Vos, G. Verbeken, M. Merabishvili, N. Chanishvili, M. Vaneechoutte, M. Zizi, et al. “The Phage Therapy Paradigm: Prêt-à-Porter or Sur-Mesure?” Pharmaceutical Research 28, no. 4 (April 2011): 934–937.
Snitkin, E. S., A. M. Zelazny, P. J. Thomas, F. Stock, Nisc Comparative Sequencing Program Group, D. K. Henderson, T. N. Palmore, and J. A. Segre. “Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing.” Science Translational Medicine 4, no. 148 (August 22, 2012): 148ra16.
Young, R., and J. J. Gill. “Microbiology. Phage Therapy Redux—What Is to Be Done?” Science 350, no. 6265 (December 4, 2015): 1163–1164.
Chapter 20. The Blood Orange Tree
Keller, Evelyn Fox. A Feeling for the Organism, 10th Anniversary Edition: The Life and Work of Barbara McClintock. New York: Henry Holt, 1983.
Chapter 21. Moment of Truth
Bhargava, N., P. Sharma, and N. Capalash. “Quorum Sensing in Acinetobacter: An Emerging Pathogen.” Critical Reviews in Microbiology 36, no. 4 (November 2010): 349–360.
Borges, A. L., J. Y. Zhang, M. F. Rollins, B. A. Osuna, B. Wiedenheft, and J. Bondy-Denomy. “Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity.” Cell 174, no. 4 (August 9, 2018): 917–925.e10.
Erez, Z., I. Steinberger-Levy, M. Shamir, S. Doron, A. Stokar-Avihail, Y. Peleg, S. Melamed, et al. “Communication between Viruses Guides Lysis-Lysogeny Decisions.” Nature 541, no. 7638 (January 26, 2017): 488–493.
Harding, C. M., S. W. Hennon, and M. F. Feldman. “Uncovering the Mechanisms of Acinetobacter baumannii Virulence.” National Review of Microbiology 16, no. 2 (February 2018): 91–102.
Logan, L. K., S. Gandra, A. Trett, R. A. Weinstein, and R. Laxminarayan. “Acinetobacter baumannii Resistance Trends in Children in the United States, 1999–2012.” Journal of the Pediatric Infectious Disease Society (March 22, 2018).
Young, R. “Phage Lysis: Three Steps, Three Choices, One Outcome.” Journal of Microbiology 52, no. 3 (March 2014): 243–258.
Chapter 22: The Bold Guess
Meldrum, M. “‘A Calculated Risk’: The Salk Polio Vaccine Field Trials of 1954.” British Medical Journal 317, no. 7167 (October 31, 1998): 1233–1236.
Nguyen, S., K. Baker, B. S. Padman, R. Patwa, R. A. Dunstan, T. A. Weston, K. Schlosser, B. Bailey, T. Lithgow, M. Lazarou, A. Luque, R. Rohwer, R. S. Blumberg, and J. J. Barr. “Bacteriophage Transcytosis Provides a Mechanism to Cross Epithelial Cell Layers.” MBio 8, no. 6 (November 21, 2017).
Chapter 24. Second-Guessing
Sacks, Oliver. Awakenings. New York: Vintage, 1999.
Chapter 26. The Darwinian Dance and the Red Queen’s Pursuit
Brockhurst, M. A., T. Chapman, K. C. King, J. E. Mank, S. Paterson, and G. D. Hurst. “Running with the Red Queen: The Role of Biotic Conflicts in Evolution.” Proceedings of the Royal Society B: Biological Sciences 281, no. 1797 (December 22, 2014).
Regeimbal, J. M., A. C. Jacobs, B. W. Corey, M. S. Henry, M. G. Thompson, R. L. Pavlicek, J. Quinones, R. M. Hannah, M. Ghebremedhin, N. J. Crane, D. V. Zurawski, N. C. Teneza-Mora, B. Biswas, and E. R. Hall. “Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues Mice from Acinetobacter baumannii Wound Infections.” Antimicrobial Agents and Chemotherapy 60, no. 10 (October 2016).
Scholl, D., J. Kieleczawa, P. Kemp, J. Rush, C. C. Richardson, C. Merril, S. Adhya, and I. J. Molineux. “Genomic Analysis of Bacteriophages Sp6 and K1-5, an Estranged Subgroup of the T7 Supergroup.” Journal of Molecular Biology 335, no. 5 (January 30, 2004): 1151–1171.
Chapter 27. The Last Dance
Rohwer, Forest, Heather Maughan, Merry Youle, and Nao Hisakawa. Life in Our Phage World: A Centennial Field Guide to the Earth’s Most Diverse Inhabitants. San Diego: Wholon, 2014.
Summers, W. C. “The Strange History of Phage Therapy.” Bacteriophage 2, no. 2 (April 1, 2012): 130–133.
Chapter 28. The Buddha’s Gift
Mukherjee, Siddhartha. “The Rules of the Doctor’s Heart.” New York Times, October 24, 2017. https://www.nytimes.com/2017/10/24/magazine/the-rules-of-the-doctors-heart.html.
Chapter 29. Grand Rounds
BMJ 2018, 363 doi: https://doi.org/10.1136/bmj.k4762. (Published 08 November 2018.
CDC Telebriefing on Today’s Drug-resistant Health threats. https://www.cdc.gov/media/releases/2013/t0916_health-threats.html.
Chan, B. K., P. E. Turner, S. Kim, H. R. Mojibian, J. A. Elefteriades, and D. Narayan. “Phage Treatment of an Aortic Graft Infected with Pseudomonas aeruginosa.” Evolution, Medicine, and Public Health 2018, no. 1 (2018): 60–66.
Davies, Madlen. “A Game of Chicken: How Indian Poultry Farming Is Creating Global Superbugs.” Bureau of Investigative Journalism. January 2018. https://www.thebureauinvestigates.com/stories/2018-01-30/a-game-of-chicken-how-indian-poultry-farming-is-creating-global-superbugs.
Dedrick RM, Guerrero-Bustamante CA, Garlena RA, et al. “Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.” Nat Med. 2019; 25(5):730-733. doi:10.1038/s41591-019-0437-z.
Garrett, L., and R. Laxminarayan “Antibiotic-Resistant ‘Superbugs’ Are Here.” https://www.cfr.org/expert-brief/antibiotic-resistant-superbugs-are-here.
Hall, William. Superbugs: An Arms Race against Bacteria. Cambridge, MA: Harvard University Press, 2018.
“High-Level Meeting on Antimicrobial Resistance.” United Nations General Assembly, September 2016. https://www.un.org/pga/71/event-latest/high-level-meeting-on-antimicrobial-resistance.
Jennes, S., M. Merabishvili, P. Soentjens, K. W. Pang, T. Rose, E. Keersebilck, O. Soete, et al. “Use of Bacteriophages in the Treatment of Colistin-Only-Sensitive Pseudomonas aeruginosa Septicaemia in a Patient with Acute Kidney Injury—a Case Report.” Critical Care 21, no. 1 (June 4, 2017): 129.
Lyon, J. “Phage Therapy’s Role in Combating Antibiotic-Resistant Pathogens.” Journal of the American Medical Association 318, no. 18 (November 14, 2017): 1746–1748.
OECD. “Stemming the Superbug Tide: Just a Few Dollars More.” OECD Health Policy Studies. Paris: OECD Publishing, 2018. https://doi.org/10.1787/9789264307599-en.
Schooley, R. T., B. Biswas, J. J. Gill, A. Hernandez-Morales, J. Lancaster, L. Lessor, J. J. Barr, et al. “Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails to Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection.” Antimicrobial Agents and Chemotherapy 61, no. 10 (October 2017).
Servick, K. “U.S. Center Will Fight Infections with Viruses.” Science 360, no. 6395 (June 22, 2018): 1280–1281.
Stockton, Ben. “Antibiotics in Agriculture: The Blurred Line between Growth Promotion and Disease and Prevention.” Bureau of Investigative Journalism. September 2018. https://www.thebureauinvestigates.com/stories/2018-09-19/growth-promotion-or-disease-prevention-the-loophole-in-us-antibiotic-regulations.
Stockton, B., Davies, M., Meesaraganda, R. “
Zoetis and Its Antibiotics for Growth in India.”
Veterinary Record 183 (October 2018), 432–433. https://veterinaryrecord.bmj.com/content/183/14/432.
Watts, G. “Phage Therapy: Revival of the Bygone Antimicrobial.” Lancet 390, no. 10112 (December 9, 2017): 2539–2540.
Epilogue
Davidson, J. E., K. Powers, K. M. Hedayat, M. Tieszen, A. A. Kon, E. Shepard, V. Spuhler, et al. “Clinical Practice Guidelines for Support of the Family in the Patient-Centered Intensive Care Unit: American College of Critical Care Medicine Task Force 2004–2005.” Critical Care Medicine 35, no. 2 (February 2007): 605–622.
Davidson, J. E., and S. A. Strathdee. “The Future of Family-Centred Care in Intensive Care.” Intensive and Critical Care Nursing (March 29, 2018).
Davydow, D. S., J. M. Gifford, S. V. Desai, D. M. Needham, and O. J. Bienvenu. “Posttraumatic Stress Disorder in General Intensive Care Unit Survivors: A Systematic Review.” General Hospital Psychiatry 30, no. 5 (September–October 2008): 421–434.
“Monitoring Global Progress on Addressing Antimicrobial Resistance: Analysis Report of the Second Round of Results of AMR Country Self-Assessment Survey 2018.” http://apps.who.int/iris/bitstream/handle/10665/273128/9789241514422-eng.pdf.
Palms, D. L., L. A. Hicks, M. Bartoces, et al. “Comparison of Antibiotic Prescribing in Retail Clinics, Urgent Care Centers, Emergency Departments, and Traditional Ambulatory Care Settings in the United States.” JAMA Internal Medicine 178, no. 9 (2018): 1267–1269. doi:10.1001/jamainternmed.2018.1632.
“Tracking Progress to Address AMR.” AMR Industry Alliance. January 2018. https://www.amrindustryalliance.org/progress-report.
Praise for
THE PERFECT PREDATOR
Amazon, “Best Books of 2019 (Science)”
Goodreads Choice Awards, Semifinalist (Science & Technology)
STAT News, “Best Health and Science Books to Read This Summer”
Finalist for the Chanticleer International Book Awards for Narrative Nonfiction and Memoir
“A memoir that reads like a thriller.”
—New York Times Book Review
“A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse—and what happens when standard health care falls short.”
—Scientific American
“[A] medical thriller for the antibiotic-resistant age.”
—Smithsonian
“[A] real page-turner.”
—Science News
“The Perfect Predator may be the best and most important book I’ve ever read… [A] personal and moving odyssey.”
—Louis R. Franzini, reviewer for The Florida-Times Union and author of Just Kidding
“[A] gripping and intriguing medical thriller… This page-turner of a couple’s determination to survive also serves as a dire warning regarding the consequences of the overuse of antibiotics.”
—Publishers Weekly (starred review)
“A real-life medical thriller… fast paced [and] the writing is always infused with humor, hope, and intelligence, and the couple’s remarkable story is grounded in real-life details that bring readers directly into their world. Dark, surreal, poetic.”
—Kirkus Reviews
“[A] riveting tale… The saga reads like a thriller.… Remarkable passages from Patterson [describe] how he interpreted events through veils of feverish delirium, pain-killer fog, and coma.”
—Laurie Garrett, The Lancet, author of The Coming Plague and Betrayal of Trust
“The story of a woman fighting for her husband’s life is interesting in and of itself, but this book is so much more than that. It was written by a scientist who used her public health training to discover a solution to a problem; it just so happens that the solution she found may be an answer to one of the most urgent health problems in the world.”
—The American Journal of Public Health
“If you’re looking for a gift for a young person currently considering a career in science or medicine, this is the book to buy.”
—The American Journal of Tropical Medicine and Hygiene
“[Tom’s case is a] case that may mark a turning point in medicine.”
—American Association of Medical Colleges Newsletter
“At once terrifying and inspiring, The Perfect Predator is a brilliant race-against-the-clock medical thriller that is also a celebration of love, commitment, and the power of scientific collaboration.”
—Steven Johnson, New York Times bestselling author of Where Good Ideas Come From and The Ghost Map
“A riveting, pulse-pounding medical thriller that just happens to be true. Steffanie Strathdee is expert at weaving science into compulsively readable prose.”
—Tess Gerritsen, New York Times bestselling author of The Shape of Night
“A remarkable story of love, resilience, the science of discovery, and quite possibly the future of medicine.”
—Richard Horton, FRCP, FMedSci, Editor-in-Chief, The Lancet
“A thriller, a detective story, and at its core a profound romance, The Perfect Predator is [a] breathtaking story.… It’s a warning of the havoc that awaits us as antibiotics lose their power, and a glimpse of the science that could hold that dark future at bay—if we can summon the funding and the political will to create it.”
—Maryn McKenna, Senior Fellow at The Center for the Study of Human Health at Emory University and author of Big Chicken and Superbug
“The Perfect Predator is a compelling and heart-wrenching medical drama that would be completely unbelievable—if it weren’t 100% true! Strathdee and Patterson masterfully weave together the personal, medical, and scientific strands of their battle against one of the world’s worst superbugs, bringing not just Patterson, but a century-old medical technology back from the brink of death. This first-hand account of the front lines of the battle against the scourge of antimicrobial resistance underscores the human cost underlying the bland statistics.”
—Rob Knight, PhD, Director, Center for Microbiome Innovation, University of California San Diego and author of Follow Your Gut and Dirt Is Good
“I simply could not put down the book. It reads like a fast-paced, detective thriller.”
—Madhukar Pai, MD, PhD, Professor and Canada Research Chair in Epidemiology & Global Health, McGill University, Montreal
“One of the single most compelling personal stories we’ve ever heard.”
—Arielle Eckstut and David Henry Sterry, authors of The Essential Guide to Getting Your Book Published
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The Perfect Predator Page 33
