by David Shenk
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Shift from “Senility” to “Alzheimer’s Disease”
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Alzheimer’s Caregiving
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King Lear
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Morris Friedell
The essays “Introduction to Myself and My Plight,” “Incipient Dementia: A Victim’s Perspective,” “Love in the Twilight Zone,” and “The Road to Alzheimer’s” are published, among many others, on Morris’s Internet home page: http://members.aol.com/MorrisFF.
Human Suffering
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Alzheimer’s Disease and Science
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Longevity
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Jonathan Swift
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Willem de Kooning
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Mnemonics
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Frederick Law Olmsted
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Soliloquies
Page 9: Michaud, Paulette. Early Stages: Changing Our Views of Alzheimer’s. New York: Alzheimer’s Association, 1998.
Page 27: Michaud, Paulette. Early Stages: Changing Our Views of Alzheimer’s. New York: Alzheimer’s Association, 1998.
Page 43: Henderson, Cary Smith. Partial View: An Alzheimer’s Journal Dallas: Southern Methodist University Press, 1998.
Page 61: Snyder, Lisa. Speaking Our Minds: Personal Reflections from Individuals with Alzheimer’s. New York: W.H. Freeman, 1999.
Page 71: Rose, Larry. Show Me the Way to Go Home. Forest Knolls, California: Elder Books, 1995.
Page 85: Toward, Jeffrey. Interviews with early-stage patients (unpublished). Houston: University of Texas Center on Aging, 1997.
Page 111: Snyder, Lisa. Speaking Our Minds: Personal Reflections from Individuals with Alzheimer’s. New York: W.H. Freeman, 1999.
Page 131: Originally posted on Alzheimer List, 1998, at http://www.adrc.wustl.edu/alzheimer
Page 147: Originally posted on Alzheimer List, 1998.
Page 161: Originally posted on Alzheimer List, 1998.
Page 177: Originally posted on Alzheimer List, 1999.
Page 191: Originally posted on Alzheimer List, 1999.
Page 215: Originally posted on Alzheimer List, 1998.
Page 227: Petrovski, Sue. Return Journey. Book in progress.
Page 241: Morris Friedell, “The Loneliness of a Person with Early Alzheimer’s Disease,” published online at http://members.aol.com/MorrisFF/
INDEX
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Abstract Expressionism, 195–206
abstract thinking, 36, 37, 125
acetylcholine, 62–63
Addison, Thomas, 80
Addison’s disease, 80
adrenal glands, 80
adrenalin, 46
agnosia, 119
AIDS, 38, 80
alcoholism, 38, 195–96, 197, 229
Alcott, Bronson, 83
Alcott, Louisa May, 217–19
alpha rhythm, 38
aluminum, 138–40
Aluminum Association, 139
Alzheimer, Alois, 12–15, 22–26, 64, 68–69, 74–84, 102, 133, 143, 162–63, 182, 245
Alzheimer Disease Research Center, 91
Alzheimer List (website), 91–97, 121, 223
Alzheimer Research Forum, 63–64
Alzheimer’s Association, 32, 209
Alzheimer’s disease:
aesthetic experience in, 192–206
awareness stage of, 94–97, 103–4, 192–94
causes of, 68–70, 73, 118–20, 137–40, 151, 155–56
cellular ultrastructure of, 133–34, 143–46
childlike behavior in, 121–30
coping mechanisms for, 32–33, 114
costs of, 5, 65, 66, 88–89
cure for, 39, 62, 67, 97, 146, 178, 209–14, 228, 235, 243–46, 251
death from, 4, 22, 37, 40, 62, 223–26
as degenerative condition, 19–22, 40, 97, 112–30, 141
diagnosis and testing of, 19–22, 31, 35–39, 94–97, 115, 116, 127–28, 192
as disease, 74–84, 129–30, 133, 137–38, 140, 142, 152–53, 250
early stages of, 31–33, 36, 37–42, 47, 63, 94–97, 114, 154, 231
environmental factors in, 155–56
identification of, 12–15, 22–26, 74–84
immunity to, 68, 137
incidence of, 5, 30–31, 65–67, 73–74, 132–34, 163–65
insidious onset of, 17–22, 32–35, 67, 103, 200, 221, 250
late stages of, 21–22, 37, 69, 119, 128, 130, 201, 216–26
in men vs. women, 67
middle stages of, 36–37, 39–40, 63, 103–4, 112–18, 119, 130
name of, 78–84, 183
neurological basis of, 21–26, 70–78, 118–20, 209–24; see also neurons
postawareness stage of, 103–4, 113, 120, 198–99
prevention of, 228–29
as process, 64–65, 79–80, 221–24
public awareness of, 136–43
as public health problem, 5, 30–32, 65–67, 132–38, 163
reality of, 27, 93–94, 114–16, 147
rehabilitation in, 94–95, 247–52
research on, see research, Alzheimer’s
resources for, 261–64
retrogenesis in, 117–30, 221–24
symptoms of, 13, 19–21, 63, 115, 142
treatment for, 39, 137, 209–14, 243–46
vaccine for, 209–14, 243–46
Alzheimer’s Weekly, 63
American Association of Retired Persons (AARP), 132
amino acids, 50
amnesia, 46–49, 201, 218–19
amygdala, 45–46, 118, 125
amyloid cascade hypothesis, 152, 155
amyloid precursor protein (APP), 144, 184, 246
amylum, 144
Angell, Roger, 34
anger, 12, 13, 118, 121–22, 129–30
animal rights, 184–85
Annesley, Bryan, 89–90, 169–70
Annesley, Cordell, 90, 169
anosognosia, 120
AN 1792, 209–14
Antabuse, 195–96
anterograde amnesia, 46–49, 218–19
antibodies, 2
09–14, 243–46
anti-inflammatory drugs, 229
antioxidants, 228
anxiety, 129–30
aphasia, 13, 41, 97, 112–13, 117, 118, 169, 221
ApoE gene, 153, 189, 245
Archives of Neurology and Psychiatry, 84
Area One, 46
Area Two, 46
Aricept, 62–63, 246, 250
Aristophanes, 112
As You Like It (Shakespeare), 83
Atlantic Monthly, 1
auditory hallucinations, 13–14, 119
Auguste D., 12–15, 21, 22–26, 74–75, 76, 77–78, 163
Augustine, Saint, 45, 231–32
Auschwitz concentration camp, 96
autoimmune response, 213–14
autonomy, 33
autopsies, 22–26, 35, 139
autotoxins, 76, 102
axons, 124, 145
Babinski, Joseph François Felix, 222
Babinski sign, 222
baby boomers, 5, 65–67, 172
Bacon, Roger, 15
Barney, 40, 115
Bataan Hall, 4, 67
beta-amyloid, 143–46, 152–53, 155–57, 184, 209–14, 243–46
biopsies, 35
Biser, Sam, 140
blindness, temporary, 38
blood-brain barrier, 139, 211–12, 244
Bok, Edward, 217–21
Bonetti, David, 203
Bonhoeffer, Karl, 76
Borchelt, David, 186
Borges, Jorge Luis, 192
bovine spongiform encephalopathy (“mad cow disease”), 148–50
Boyle, John, 168, 171–72
“Brahma” (Emerson), 2
brain:
autopsies of, 22–26, 72–74, 124–25
deterioration of, 20–22, 30, 37–38, 204
as electrochemical engine, 11–12
evolution of, 23, 53, 56–57
functional areas of, 21–22, 45–49
injuries to, 38, 201, 228
modular theory of, 45–49
neurons of, see neurons
nonhuman, 178–89
pathology of, 72–84, 102, 118–20
size of, 11, 21, 37–38, 204
tumors of, 34–35
ventricular theory of, 45
weight of, 23
“white matter” of, 124
see also specific brain areas
brainstem, 24, 49, 222–24
brain waves, 38, 184
Brickman, Irving, 28, 29, 31–32, 39, 113, 114
Brocas area, 46
