The Real Happy Pill

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The Real Happy Pill Page 20

by Anders Hansen


  AXON A tendril-like offshoot from a brain cell that passes signals between the cells.

  BDNF Brain-derived neurotrophic factor. A protein created by the brain that has shown to be important for many brain functions, such as creating new brain cells, as well as for our memory and general well-being.

  CEREBELLUM Situated at the back of the skull, it is important for motor control and balance. The cerebellum makes up 10 percent of total brain volume.

  CORTEX The cerebral cortex is the brain’s outer layer and its most sophisticated part. It is also the part of the brain where major work is carried out. It consists mainly of cell bodies. The cerebral cortex is, unlike the rest of the brain, made up of six layers.

  CORTISOL A stress hormone produced by the adrenal glands (situated on top of the kidneys) that increases heart rate, blood pressure, and warns and prepares us for fight or flight. In the long term, high cortisol levels will break down the brain, especially the hippocampus.

  DOPAMINE A substance that controls well-being and, especially, motivation, drive, and reward. It is also important for concentration and movement.

  ENDOCANNABINOIDS Endogenous substances that can produce pain relief and euphoria. They have common receptors with marijuana and THC (Tetrahydrocannbinol/cannabis).

  ENDORPHINS Endogenous morphine (endogenic = originating within a cell, the body, etc.) is a group of hormones created in the brain (and the rest of the body) that can provide pain relief and euphoria.

  EXECUTIVE FUNCTIONS or COGNITIVE FUNCTIONS A collective term for functions such as impulse control and concentration, and the ability to change and adapt behavior to current surroundings.

  FRONTAL LOBE The anterior part of the brain. Logical and abstract thinking, as well as emotional control, are situated here. The frontal lobe is the most advanced part of the brain.

  GABA Gamma-aminobutyric acid. A substance that calms the brain’s activity.

  GRAY MATTER This is mainly composed of neuronal cell bodies. The gray coloring isn’t noticeable until after death. A living brain is more pink in color.

  HIPPOCAMPUS Big as a thumb. There is one hippocampus in each side of the brain. Important for memory, but also for emotional control and spatial orientation. The hippocampus is the part of the brain that is probably the most affected by physical activity.

  HPA-AXIS The hypothalamic-pituitary-adrenal axis is the brain’s most important stress control system. It starts in the area called the hypothalamus, which sends a signal to the pituitary (a gland in the brain), which in turn signals the adrenal glands to produce the stress hormone cortisol.

  HYPOTHALAMUS Central area in the brain important for blood pressure, heart rate, body temperature, and metabolism.

  MRI Magnetic Resonance Imaging. Sophisticated medical imaging technique that displays body organs in high resolution. Functional MRI (fMRI) is used to follow different areas of the brain as they are activated. This is done by measuring blood flow to the different areas. Large blood flow indicates high activity in the area. An MRI machine is the size of a small car, and you’re pushed into a tube that looks like a small tunnel. A magnetic field is created in the tunnel, and this field is so strong that the magnet that creates the field must be chilled in liquid nitrogen at a temperature of -328°F (-200°C).

  NEUROGENESIS The creation of new brain cells. Earlier it was believed that new brain cells were only created in children, but now we know that new brain cells are created throughout life—even in adults.

  NEURON Brain cell.

  NORADRENALINE Norephinephrine. A substance in the brain that controls alertness and concentration, among other things.

  ORBITOFRONTAL CORTEX Part of the cerebral cortex behind the forehead. Important for decision making and the reward system.

  PET SCAN Positron emission tomography. Sophisticated medical imaging technique where radioactive substances are injected into the body. Used for research and in health care to locate tumors, among other things.

  PITUITARY A pea-sized gland in the brain that regulates several of the body’s important hormones like the stress hormone cortisol. The P in pituitary is the same P in the name of our body’s stress control system, the HPA axis.

  PREFRONTAL CORTEX Anterior part of the frontal lobe. The seat for our most sophisticated intellectual functions, like how to anticipate the future, adapt or conform to changes, put off rewards, and act toward others.

  SEROTONIN A substance in the brain that is vital for our mood, especially for calm and inner strength.

  SSRI Selective serotonin reuptake inhibitor. The most common pharmaceutical used in treating depressive disorders. Acts by increasing levels of the neurotransmitter serotonin in the brain but also affects noradrenalin and dopamine.

  SYNAPSE The small space between two brain cells where the contact between cells happens. The cells don’t touch but send out signal substances such dopamine, serotonin, and GABA to one another.

  TEMPORAL LOBE The part of brain behind the temple. Important for memory, among other things.

  THALAMUS Central in the brain where a lot of information passes through. Functions at times like a filter to make sure we’re not overloaded with information.

  THE REPTILIAN BRAIN The part of the brain that has been preserved through evolution, and that we have in common with simpler mammals. Functions like our fight-or-flight mode are there. The reptilian brain makes us react to danger (like running away) but not anticipate danger beforehand.

  WHITE MATTER The connections between brain cells. They are situated beneath the gray matter and consist of long tendril-like axons between the brain cells. The white color is from the axons being coated in a fatty substance called myelin that increases the speed of signal transmission.

  REFERENCES

  1. Your changeable brain

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  Smith, S et al. (2015). A positive-negative mood of population covariation links brain connectivity, demographics, and behavior. Nature Neuroscience, 18:565–7, DOI: 10.1038/nn.4125.

  Voss, M et al. (2010). Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Frontiers in Aging Neuroscience, DOI:10.3389/fnagi.2010.00032.

  2. Run away from stress

  Agudelo, L et al. (2014). Skeletal muscle PGC-1a1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell, 159(1):33–45.

  American Psychological Association, 2015. Stress in America: paying with our health.

  Bonhauser, M et al. (2005). Improving physical fitness and emotional well-being in adolescents of low socioeconomic status in Chile: results of a school-based controlled trial. Health Promotion International, DOI: 10.1093/heapro/dah603.

  Colcombe, S, Erickson KI., Scalf, PE et al. (2006). Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci, 61:1166–70.

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  Zschuncke, E et al. (2015). The stress-buffering effect of acute exercise: Evidence for HPA axis negative feedback. Psychoendocrinology, 51:414–25, DOI:10.1016/j.psyneuen.2014.10.019.

  3. Improved concentration

  Beak, D et al. (2014). Effect on treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/hyperactivity disorder rats. Journal of Exercise Rehabilitation.

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  Eun Sang, J et al. (2014). Duration-dependence of the effect of treadmill exercise on hyperactivity in attention deficit hyperactivity disorder rats. Journal of Exercise Rehabilitation, 10(2):75–80.

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  Silva, A et al. (2015). Measurement of the effect of physical exercise on the concentration of individuals with ADHD. PLOS One, DOI:10.1371/journal.pone.0122119.

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  4. The real happy pill

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  Lang, U et al. (2004). BDNF Serum concentration in healthy volunteers are associated with depression-related personality traits. Neuropsychopharmacology, 29:795–98. DOI:10.1038/sj.npp.1300382.

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  5. Jog your memory

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  Ericson, K et al. (2010). Exercise training increases size of hippocampus and improves memory. PNAS, DOI:10.1073/pnas.1015950108.

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  Fastenrath, M et al. (2014). Dynamic modulation of amygdala-hippocampal connectivity by emotional arousal. The Journal of Neuroscience, 34(42):13935–47. DOI:10.1523/JNEUROSCI.0786-14.2014.

  Kohman, R et al. (2011). Voluntary wheel running reverses age-induced changes in hippocampal gene expression. PLOS One, DOI:10.1371/journal.pone.0022654.

  Leraci, A et al. (2015). Physical exercise and acute restraint stress differentially modulate hippocampal BDNF transcripts and epigenic mechanism in mice. Hippocampus, DOI:10.1002/hipo.22458.

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  Pereira, A et al. (2007) An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. PNAS, DOI:10.1073/pnas.0611721104.

  Rhodes, J et al. (2005). Neurobiology of mice selected for high voluntary wheel-running activity. Integr Comp Biol, 45:438–55.

  Roig, M et al. (2012). A single bout of exercise improves motor memory. PLOS One, DOI:10.1371/journal.pone.0044594.

  Schmidt-Kassow, M et al. (2013). Physical exercise during encoding improves vocabulary learning in young female adults: A neuroendocrinological study. PLOS One, 8(5):e64172.

  Smith, C et al. (2009). Medial temporal lobe activity during retrieval of semantic memory is related to the age of the memory. Journal of Neuroscience, DOI:10.1523/JNEUROSCI.4545-08.2009.

  Winter, B et al. (2007). High impact running improves learning. Neurobiology of Learning and Memory, DOI:10.1016/j.nlm.2006.11.003.

  6. Train yourself to be creative

  That Mozart’s letter is a forgery is shown in How to fly a horse, a book by the American author Kevin Ashton, and in an essay by Jan Gradvall in Dagens Industri, May 2015.

  Colzato, L et al. (2013). The impact of physical exercise on convergent and divergent thinking. Frontiers in Neuroscience, DOI:10.3389/fnhum.2013.00824.

  Oppezzo, M et al. (2014). Give your ideas some legs: the positive effect of walking on creative thinking. Journal of Experimental Psychology: Learning, Memory, and Cognition 2014, 40;(4):1142–52.

  Steinberg, H et al. (1997). Exercise enhances creativity independently of mood. Br J Sports Med, 31:240–45.

  7. The growing brain

  Åberg, M et al. (2009). Cardiovascular fitness is associated with cognition in young adulthood. PNAS USA, Dec 8; 106(49):20906–11.

  Burzynska, A et al. (2014). Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults. PLOS One, DOI:10.1371/journal.pone.0107413.

  Castelli, D et al. (2007). J Sport Exerc. Psychol, Apr; 29(2):239–52 [sic].

  Chaddock, C et al. (2010). A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res, 1358:172–83.

  Chaddock-Hayman, L et al. (2014). Aerobic fitness is associated with greater white matter integrity in children. Frontiers in Human Neuroscience, DOI:10.3389/fnhum.2014.00584.

  Davis, C et al. (2011). Exercise improves executive function and achievement and alters brain activation in overweight children: A randomized controlled trial. Health Psychology, vol. 30(1):91–98.

  Hillman, C et al. (2009). The effect of acute treadmill walking on cognitive control and academic achievement in preadolescent children. Neuroscience, 159(3):1044–54.

  Ma, J et al. (2015). Four minutes of in-class high-intensity interval activity improves selective attention in 9 to 11-year-olds. Applied Physiology Nutrition and Metabolism 2014, DOI:10.1139/apnm-2014–0309.

  Martikainen,
S et al. (2013). Higher levels of physical activity are associated with lower hypothalamic–pituitary–adrenocortical axis reactivity to psychosocial stress in children. J Clin Endocrinol Metab, 98(4):e619–27, DOI:10.1210/jc.2012-3745.

  Metha, R et al. (2015). Standing up for learning: A pilot investigation on the neurocognitive benefits of stand-biased school desks. Int. J. Environ. Res. Public Health, 13, 0059. DOI:10.3390/ijerph13010059.

  Nyberg, J et al. (2013). Cardiovascular fitness and later risk of epilepsy: a Swedish population-based cohort study. Neurology, 81(12):1051–7, DOI:10.1212/WNL.0b013e3182a4a4c0.

  Rasberry, C et al. (2011). The association between school-based physical activity, including physical education, and academic performance: a systematic review of the literature. Prev. Med, DOI:10.1016/j.ypmed.2011.01.027.

  Raine, L et al. (2013). The influence of childhood aerobic fitness on learning and memory. PLOS One, DOI:10.1371/journal.pone.0072666.

  Rauner, R et al. (2013). Evidence that aerobic fitness is more salient than weight status in predicting standardized math and reading outcomes in fourth-through eighth-grade students. The Journal of Pediatrics, DOI:10.1016/j.jpeds.2013.01.006.

  Tine, M et al. (2014). Acute aerobic exercise: an intervention for the selective visual attention and reading comprehension of low-income adolescents. Frontiers in Psychology, DOI:10.3389/fpsyg.2014.00575.

  Van Eimeren et al. (2008). White matter microstructures underlying mathematical abilities in children. NeuroReport, DOI:10.1097/WNR.0b013e328307f5c1.

  8. Healthy aging for the brain

  Colcombe, S et al. (2006). Aerobic exercise training increases brain volume in aging humans. J Gerontology A Biol Sci Med Sci, 61:1166–70.

  Hyodo, K et al. (2015). The association between aerobic fitness and cognitive function in older men mediated by frontal lateralization. Neuroimage, DOI:10.1016/j.neuroimage.2015.09.062.

 

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