by Greg Egan
‘You’ve spoken with Martha?’
‘Yeah, through the wall of a tent. She couldn’t get away herself, but it’s not exactly maximum security back there. They’ve got poor Dr Sukardi tied up somewhere and guarded round the clock, but they seem to think that’s all that matters, as if he’s our own little tinpot colonel and we’re all helpless drones without him.’
Madhusree had a tranquilliser gun tucked into the back of her shorts. Prabir asked nervously, ‘What was in the darts?’
She replied almost absent-mindedly, ‘The normal sedative, but I added something to wreck the catalytic portion. It’s a self-degrading molecule, that’s why it’s safe to use on so many species: half of it forms an enzyme that lyses the whole thing into harmless junk in the presence of ATP, so it doesn’t require anything fancy in the organism to detoxify it. But it breaks itself down so quickly once it enters the bloodstream that if you disable the enzyme, it makes a huge difference: the potency goes up a thousandfold.’ She turned to him and added pointedly, as if she’d finally realised what he’d been fearing, ‘We have enzymes in the liver that can deal with it, though. It’s still not toxic to humans.’
She finished her inventory. ‘OK, this is great. You start unmounting these and stacking them on the deck. I’ll go and get the inflatables. I should be back in about ten minutes.’
Prabir said, ‘I must be slow, but I think I’m missing something. Where are we going with all this? What’s the plan?’
Madhusree smiled, proud and conspiratorial, as if Amita might walk in at any moment and ask why they were whispering.
‘What do you think? We’re heading south.’
Prabir followed his instructions while Madhusree swam out to the expedition’s ship. Then he checked the sentry curled up on the deck; the man was still breathing, slowly and deeply.
He stood and waited for Madhusree to return. Simply by travelling with her, he’d endanger her to some degree. But Grant had remained uninfected, after handling every Teranesian species he’d touched himself, after they’d kissed. With no one to keep him grounded he’d let his imagination run wild: the only hard facts were that a trace of the gene had been found in his bloodstream, and the fishermen had changed in some way that nobody wanted to talk about.
Madhusree appeared from behind the ship, rowing a bright-orange inflatable dinghy towards him, with a second one in tow, loaded with cargo. For one awful moment, Prabir wondered if she planned to get to safety under human power alone, but both dinghies had outboard motors, she was just minimising noise. He looked back towards the camp; the sentries had been changed around ten p.m., and it was now nearly twenty to three. In the moonlight, the orange polymer might as well have been fluorescent. Would they have until dawn, or just till the hour, to vanish over the horizon?
Madhusree brought the dinghies up against the boat. ‘Hand those down to me, one at a time.’
Prabir passed her the first of the machines. ‘What’s this all for?’ There were already half a dozen identical silver boxes in the second dinghy, as well as bottles of reagents, and four large fuel cans.
‘To monitor you, of course. And treat you, if necessary.’
‘Are you serious?’
‘I hope it won’t be necessary. I’m hoping nothing will happen before we reach Darwin.’
‘Darwin? If the Australians get the slightest idea of what I’m carrying, they’ll lock me in a hut in the middle of the desert on top of their nuclear waste dump.’
‘No, they’ll deport you back to Canada in a military jet with biohazard containment facilities, then send you the bill. I can think of worse fates if we head in other directions.’
Prabir said, ‘What exactly is it you’re hoping won’t happen en route?’
‘If I knew that, we’d be travelling lighter.’ She slid the last machine into place between the others and tested the whole pile for stability. Then she tossed him a life jacket; she was already wearing one herself. ‘OK. Get in.’
‘I’ll ride in the back.’
‘You just don’t want to help me row.’
Prabir climbed over the guard rail and lowered himself into the second dinghy. He was afraid it would sink perilously low, but the air-filled walls gave it a lot of buoyancy and his weight barely made a difference. The tide was high, and Madhusree seemed to have crossed right over the submerged reef on her way in, without bothering to steer any special course.
She began rowing them laboriously towards the open sea. ‘Remember Orr, in Catch-22?’ she asked cheerfully. ‘He rowed a lifeboat all the way to Sweden.’
‘I remember.’ He’d given her the book for her eleventh birthday. ‘But I take it we’re going to stop at Yamdena and hitch a ride in something more seaworthy?’
‘That’s the plan. I wouldn’t want to cross the Arafura Sea in these things.’
Prabir was silent for a while, then he said, ‘Are you angry with me?’
Madhusree laughed. ‘How can I be angry? Not only do I have the first authenticated specimen of a Teranesian mammal, I have exclusive access to all his biochemical data. I’ll be able to spin this into a PhD, for sure.’ She turned to him without missing a stroke and said, ‘We should have done all of this differently. You should have come along as part of the expedition. We should have been open about everything from the start. But it doesn’t matter now. Their work’s been acknowledged, and someone will complete it. That’s good enough for me.’
They were well past the reef, but still in easy sight from the beach. Madhusree’s arms were trembling from fatigue; she’d swum several hundred metres before picking up the oars. Prabir said, ‘Swap places, I’ll do some rowing.’
‘OK.’
They swam between the dinghies; it was easier than trying to leap across the gap without landing on something. Prabir took the oars and settled into a rhythm. The emptiness ahead of them, the useless stars, the circle of moonlit water that followed the boat were all the same as they’d been eighteen years before.
He struggled to stay in the present. ‘How many people are hiding in the jungle?’
‘Ten, now.’
‘So what are they going to live on?’
‘It’s not that hard to smuggle out food. Anyway, we’ve already sent word up to Ambon; the situation should be resolved in a couple of days. I gather that it’s all a matter of diplomats calling in favours, until one of West Papua’s major aid donors agrees to apply some muscle. I know that sounds horribly convoluted, but it’s probably a lot safer than Ambon sending in a warship.’
‘Yeah. Can you see anything happening back on the beach?’
Madhusree had brought a pair of binoculars. ‘That guy’s still lying where he fell.’ She added teasingly, ‘Still glowing at body temperature.’
‘I never thought you’d killed them,’ Prabir protested.
‘You’re a bad liar.’
‘Martha might have. Not you.’
‘You don’t think I’m commando material?’ Madhusree sounded disappointed.
‘I certainly hope not.’ He glanced over his shoulder at her; she was grinning. She didn’t remember the soldier in the grass, bleeding slowly to death. He joked, ‘I knew I should have never let you take up muay thai. All that brutality. You’ve been scarred for life.’
After a while they swapped places again. Prabir looked back with the binoculars in IR mode, waiting not only for the prone soldier to vanish, but for the haze of distortion above the water to swallow the entire beach.
‘You can start the motor.’
Madhusree hit the ignition and her dinghy shot forward, pulling the connecting rope taut. The motor was running on diesel, but it was so quiet that Prabir almost wept. They could have fired it up half an hour ago; they’d been making more noise just by talking.
‘Do you think they’ll come after us?’ she asked. ‘It might not be hard to guess the right direction.’
Prabir said, ‘I don’t know if I’m worth the trouble to them. As long as I’m not heading for their
country, I’m someone else’s problem now.’
The dinghy’s outboard motor had its own GPS, its own inertial navigation, its own autopilot. Madhusree zeroed in on their chosen destination on a map displayed on a small panel, confirmed the choice, then left the machine to steer. The only thing not automated was obstacle avoidance; they’d have to take over manually if they ran into shipping, and with any luck that would mean cutting the motor and waiting to be rescued, not swerving wildly to avoid getting mown down.
As dawn approached, she tossed Prabir a plastic-wrapped hypodermic. ‘If you’re going to be paranoid, you’ll have to take your own blood samples.’
‘Urgh. This should be fun.’ He tore open the packet; there was a disinfectant swab enclosed, like an airline’s miniature scented towel. He pulled off his belt and tightened it around his left arm. ‘I feel like a drug addict.’
Madhusree shook her head despairingly. ‘Junkies use sonics: transdermal acoustic delivery systems that make the skin permeable to small molecules like opiates. There’s no risk of infection, because viruses are too large to get through. How do you think hepatitis C got wiped out?’
‘I knew all that,’ he lied. He applied the swab then slid the needle carefully into the crook of his elbow, but the dinghy lurched just as he was applying pressure, and the needle transected the vein. ‘Fuck.’ He steeled himself, then tried again at a different point; this time the blood spurted satisfyingly into the low-pressure sample tube. ‘How often do we have to do this?’
‘Every couple of hours at first, just to see what’s going on.’
Prabir left the hypodermic in place and flung the tube of blood across to Madhusree. A valve had shut off the flow automatically, but it was awkward trying to stop the needle slipping out. ‘Have you got some tape or something? I might as well keep this in.’
‘Good idea. There’s an anticoagulant coating on the needle, so it won’t clog up. But you knew that, of course.’ She tossed him a packet of band aids.
‘What are you looking for? In the samples?’
‘Levels of the gene, tissue types affected.’ Madhusree tinkered with one of Grant’s silver boxes until it emitted an encouraging boot-up chime.
‘Tissue types?’
She fed the blood to the machine. ‘If the gene is being incorporated into various kinds of cells in your body, occasionally one will break free and end up in your bloodstream. If I sort the cells with flow cytometry before bursting them and probing the DNA, I can track what’s happening.’
Prabir said, ‘It should only be in my testes, though, shouldn’t it? I mean, it has a promoter that will only switch it on during meiosis, so why bother incorporating anywhere else?’
The machine began whirring. Madhusree looked up and said encouragingly, ‘I hope it hasn’t even got a hold there. We’ll probably never know how it got into your bloodstream, but it certainly hasn’t come to you via another mammal, so its past experience is of limited relevance. Nothing works the first time in a new environment.’
‘You don’t believe in Furtado’s theory, then?’
She laughed and said flatly, ‘No.’
Prabir didn’t challenge her to provide her own explanation; he didn’t want to derail her, he didn’t want to erode her confidence. She’d track the gene through his body, and they’d fight it. However it worked, whatever it did.
When the sun cleared the water there was no land in sight, though Prabir could see Teranesia’s peak to their west through the binoculars. Straight ahead he saw nothing but sea. They wouldn’t reach Yamdena till midnight.
Madhusree said, ‘First results. Are you ready?’
‘Yeah.’
‘The São Paulo gene’s been incorporated into spermatogenic stem cells, complete with the usual promoter.’
Prabir nodded acceptingly. He’d been prepared for that, and however tainted it made him feel, a transplant could still rid him of the gene completely.
‘But it’s also present in dermal stem cells. With a different promoter.’
‘In my skin?’ He stared at her, more baffled than alarmed. ‘Why?’
Madhusree shook her head. ‘I don’t know.’
Prabir looked down at his arms and hands; they appeared perfectly normal. He lifted his shirt above his waist. There was a glossy patch on his abdomen, a shiny purplish-black region the size of a large coin. He touched it warily. The surface of his skin felt the same as ever, but when he applied enough pressure to sense what lay beneath, instead of the usual springiness of muscle he met resistance from an object as hard as bone.
‘It’s solid. It’s some kind of tumour.’ He was numb with revulsion. ‘Can you cut it out? Please?’
Madhusree said, ‘Stay calm.’
Prabir removed his life jacket and pulled off his shirt, almost dislodging the hypodermic in his haste; there were two more patches higher on his chest. He turned so Madhusree could see his back. ‘There are five,’ she announced. ‘About the same size.’
‘You could anaesthetise me with the tranquilliser gun,’ he implored her. ‘They’re not that deep. I won’t lose much blood.’ The gene would still be in his body, but he didn’t care. He wanted this visible, palpable sign of it removed.
‘Are they causing you any pain? Any burning sensation? They could be completely benign.’
‘Benign?’
Madhusree held her hands up, pleading with him for cool-headedness. ‘If there’s no pain or bleeding, they might only be replacing the normal dermis rather than invading other tissues. And if there’s no inflammation, at least they’re not provoking an autoimmune reaction.’
Prabir took several deep breaths. He’d handled a peppering with shrapnel better than this. He said, ‘There’s no pain, no inflammation.’
‘OK. I’ll synthesise growth factor blockers tailored to the receptors the cells are expressing. That should at least stabilise them.’
‘You can do that?’
‘Of course. It’s a second-year lab project: “Here’s a cultured organ with an unknown tumour. Characterise the tumour, and stop it growing.” ’ Madhusree regarded him tenderly across the narrow channel of water. ‘You’re going to be fine! We just have to be patient. We’ll get to Yamdena, we’ll get to Darwin, we’ll get to Toronto. And then we’ll fix you up for good.’
As Madhusree worked on the growth factor blockers, the hard, shiny plaques beneath his skin grew thicker and larger. New ones blossomed, on his arms and legs and buttocks. The sensation of their presence when he moved was strange, but only rarely painful, and Prabir took some comfort from their uselessness; the São Paulo gene was behaving as stupidly and randomly as a virus blundering into a brand-new host. Leprosy would have had about the same effect on his mating prospects. He’d hardly dared admit to the fear before, but as they’d left the island of the mangroves behind, he’d thought: It could have the power to do anything. It could have the power to make me rape my own sister.
It didn’t. If the fishermen had been affected in the same way as him, they’d probably been hounded for their disfigurement by a superstitious mob, and merely tried to defend themselves. What had happened with Grant had just happened; he was tired of probing it for significance.
He lay back between the fuel cans and watched the blue water around them sparkling in the morning sun.
Just before eight o’clock, Madhusree threw him a plastic tube with a clear, oily preparation, still warm from the machine; the synthesiser, on request, had welded the tube closed. When Prabir placed it in the hypodermic’s receptacle and hit the injection button, the various mating surfaces were sterilised by laser flash, then the tube was punctured at both ends and the contents driven into his vein.
He took another blood sample. Half an hour later, Madhusree had the results: the number of cells containing the gene had risen substantially, but that was hardly surprising given the visible evidence of his skin. If the blockers didn’t work there’d be no hiding his condition by the time they hit Yamdena, but he’d given Madhusre
e his account details, so even if he was crippled she could summon enough money from the net to compensate for any squeamishness people might have about giving him a ride.
He watched her at the bow of their twin vessel, checking their position against her notepad’s GPS to be sure that the motor was running true, scouring the horizon with the binoculars for landmarks, validating everything three different ways. He was not going to tell her: You’re carrying your parents’ killer. You’re saving a life that should not have been saved. He couldn’t pretend to untangle his own shame and cowardice at the thought of her knowing, from his understanding of the effect the revelation would have had on her, but he didn’t need to. He was not going to rob her of this feat. He was not going to corrupt it.
The data from his ten o’clock sample worried Madhusree. ‘Another line of dermal cells with different growth factors has taken over; I’ll have to make new blockers. And there are traces …’ She trailed off.
Prabir said, ‘Traces of what? No more tantrums, I promise.’ He joked lamely, ‘It’s got me by the balls, how much worse can it get?’
‘Traces of everything,’ Madhusree admitted. ‘Every cell type in your body that can be found in your bloodstream now has a small proportion bearing the São Paulo gene.’
‘Could that just be spillage? Whatever kind of cells the packaging around the gene is tailored for, mightn’t it work inefficiently almost anywhere?’ He was afraid, but he wasn’t going to panic again. He was suffering from something like cancer. No one died of cancer in a day.
‘I don’t know.’ Madhusree’s confidence was fraying. She was a nineteen-year-old biology student, and there was no reference site, no expert pathologist, no repository anywhere in the world with any real knowledge of what was happening to him. ‘I could synthesise antisense DNA,’ she said tentatively. ‘To bind to the transcripts from the São Paulo gene, maybe stop it being expressed.’
Prabir’s spirits soared. ‘OK! Let’s try it!’
‘I’ll wrap it in lipids similar to the ones they use in gene therapy, but it won’t get into every cell type.’
‘Some cells will get a dose, some won’t. We’ll have controls. What more can you ask for?’
