Siddhartha Mukherjee - The Emperor of All Maladies: A Biography of Cancer

by Siddhartha Mukherjee

  By the early months of 1951, however, Farber's work was growing exponentially, moving far beyond the reaches of his old laboratory. His outpatient clinic, thronged by parents and their children, had to be moved outside the hospital to larger quarters in a residential apartment building on the corner of Binney Street and Longwood Avenue. But even the new clinic was soon overloaded. The inpatient wards at Children's had also filled up quickly. Since Farber was considered an intruder by many of the pediatricians at Children's, increasing ward space within the hospital was out of the question. "Most of the doctors thought him conceited and inflexible," a hospital volunteer recalled. At Children's, even if there was space for a few of his bodies, there was no more space for his ego.

  Isolated and angry, Farber now threw himself into fund-raising. He needed an entire building to house all his patients. Frustrated in his efforts to galvanize the medical school into building a new cancer center for children, he launched his own effort. He would build a hospital in the face of a hospital.

  Emboldened by his early fund-raising success, Farber devised ever-larger drives for research money, relying on his glitzy retinue of Hollywood stars, political barons, sports celebrities, and moneymakers. In 1953, when the Braves franchise left Boston for Milwaukee, Farber and Koster successfully approached the Boston Red Sox to make the Jimmy Fund their official charity.

  Farber soon found yet another famous recruit: Ted Williams--a young ballplayer of celluloid glamour--who had just returned after serving in the Korean War. In August 1953, the Jimmy Fund planned a "Welcome Home, Ted" party for Williams, a massive fund-raising bash with a dinner billed at $100 per plate that raised $150,000. By the end of that year, Williams was a regular visitor at Farber's clinic, often trailing a retinue of tabloid photographers seeking pictures of the great ballplayer with a young cancer patient.

  The Jimmy Fund became a household name and a household cause. A large, white "piggy bank" for donations (shaped like an enormous baseball) was placed outside the Statler Hotel. Advertisements for the Children's Cancer Research Fund were plastered across billboards throughout Boston. Countless red-and-white collection canisters--called "Jimmy's cans"--sprouted up outside movie theaters. Funds poured in from sources large and small: $100,000 from the NCI, $5,000 from a bean supper in Boston, $111 from a lemonade stand, a few dollars from a children's circus in New Hampshire.

  By the early summer of 1952, Farber's new building, a large, solid cube perched on the edge of Binney Street, just off Longwood Avenue, was almost ready. It was lean, functional, and modern--self-consciously distinct from the marbled columns and gargoyles of the hospitals around it. One could see the obsessive hand of Farber in the details. A product of the 1930s, Farber was instinctively frugal ("You can take the child out of the Depression, but you can't take the Depression out of the child," Leonard Lauder liked to say about his generation), but with Jimmy's Clinic, Farber pulled out all the stops. The wide cement steps leading up to the front foyer--graded by only an inch, so that children could easily climb them--were steam-heated against the brutal Boston blizzards that had nearly stopped Farber's work five winters before.

  Upstairs, the clean, well-lit waiting room had whirring carousels and boxes full of toys. A toy electric train, set into a stone "mountain," chugged on its tracks. A television set was embedded on the face of the model mountain. "If a little girl got attached to a doll," Time reported in 1952, "she could keep it; there were more where it came from." A library was filled with hundreds of books, three rocking horses, and two bicycles. Instead of the usual portraits of dead professors that haunted the corridors of the neighboring hospitals, Farber commissioned an artist to paint full-size pictures of fairy-book characters--Snow White, Pinocchio, and Jiminy Cricket. It was Disney World fused with Cancerland.

  The fanfare and pomp might have led a casual viewer to assume that Farber had almost found his cure for leukemia, and the brand-new clinic was his victory lap. But in truth his goal--a cure for leukemia--still eluded him. His Boston group had now added another drug, a steroid, to their antileukemia regimen, and by assiduously combining steroids and antifolates, the remissions had been stretched out by several months. But despite the most aggressive therapy, the leukemia cells eventually grew resistant and recurred, often furiously. The children who played with the dolls and toy trains in the bright rooms downstairs were inevitably brought back to the glum wards in the hospital, delirious or comatose and in terminal agony.

  One woman whose child was treated for cancer in Farber's clinic in the early fifties wrote, "Once I discover that almost all the children I see are doomed to die within a few months, I never cease to be astonished by the cheerful atmosphere that generally prevails. True, upon closer examination, the parents' eyes look suspiciously bright with tears shed and unshed. Some of the children's robust looks, I find, are owing to one of the antileukemia drugs that produces a swelling of the body. And there are children with scars, children with horrible swellings on different parts of their bodies, children missing a limb, children with shaven heads, looking pale and wan, clearly as a result of recent surgery, children limping or in wheelchairs, children coughing, and children emaciated."

  Indeed, the closer one looked, the more sharply the reality hit. Ensconced in his new, airy building, with dozens of assistants swirling around him, Farber must have been haunted by that inescapable fact. He was trapped in his own waiting room, still looking for yet another drug to eke out a few more months of remission in his children. His patients--having walked up the fancy steamed stairs to his office, having pranced around on the musical carousel and immersed themselves in the cartoonish gleam of happiness--would die, just as inexorably, of the same kinds of cancer that had killed them in 1947.

  But for Farber, the lengthening, deepening remissions bore quite another message: he needed to expand his efforts even further to launch a concerted battle against leukemia. "Acute leukemia," he wrote in 1953, has "responded to a more marked degree than any other form of cancer . . . to the new chemicals that have been developed within the last few years. Prolongation of life, amelioration of symptoms, and a return to a far happier and even a normal life for weeks and many months have been produced by their use."

  Farber needed a means to stimulate and fund the effort to find even more powerful antileukemia drugs. "We are pushing ahead as fast as possible," he wrote in another letter--but it was not quite fast enough for him. The money that he had raised in Boston "has dwindled to a disturbingly small amount," he noted. He needed a larger drive, a larger platform, and perhaps a larger vision for cancer. He had outgrown the house that Jimmy had built.

  PART TWO

  AN IMPATIENT WAR

  Perhaps there is only one cardinal sin: impatience. Because of impatience we were driven out of Paradise, because of impatience we cannot return.

  --Franz Kafka

  The 325,000 patients with cancer who are going to die this year cannot wait; nor is it necessary, in order to make great progress in the cure of cancer, for us to have the full solution of all the problems of basic research . . . the history of Medicine is replete with examples of cures obtained years, decades, and even centuries before the mechanism of action was understood for these cures.

  --Sidney Farber

  Why don't we try to conquer cancer by America's 200th birthday? What a holiday that would be!

  --Advertisement published in

  the New York Times by the Laskerites,

  December 1969

  "They form a society"

  All of this demonstrates why few research scientists are in policy-making positions of public trust. Their training for detail produces tunnel vision, and men of broader perspective are required for useful application of scientific progress.

  --Michael Shimkin

  I am aware of some alarm in the scientific community that singling out cancer for . . . a direct presidential initiative will somehow lead to the eventual dismantling of the National Institutes of Health. I do not share these fe
elings. . . . We are at war with an insidious, relentless foe. [We] rightly demand clear decisive action--not endless committee meetings, interminable reviews and tired justifications of the status quo.

  --Lister Hill

  In 1831, Alexis de Tocqueville, the French aristocrat, toured the United States and was astonished by the obsessive organizational energy of its citizens. "Americans of all ages, all conditions, and all dispositions constantly form associations . . . of a thousand other kinds--religious, moral, serious, futile, general or restricted, enormous or diminutive," Tocqueville wrote. "Americans make associations to give entertainments, to found seminaries, to build inns, to construct churches, to diffuse books, to send missionaries to the antipodes. . . . If it is proposed to inculcate some truth or to foster some feeling by the encouragement of a great example, they form a society."

  More than a century after Tocqueville toured the States, as Farber sought to transform the landscape of cancer, he instinctively grasped the truth behind Tocqueville's observation. If visionary changes were best forged by groups of private citizens forming societies, then Farber needed such a coalition to launch a national attack on cancer. This was a journey that he could not begin or finish alone. He needed a colossal force behind him--a force that would far exceed the Jimmy Fund in influence, organization, and money. Real money, and the real power to transform, still lay under congressional control. But prying open vast federal coffers meant deploying the enormous force of a society of private citizens. And Farber knew that this scale of lobbying was beyond him.

  There was, he knew, one person who possessed the energy, resources, and passion for this project: a pugnacious New Yorker who had declared it her personal mission to transform the geography of American health through group-building, lobbying, and political action. Wealthy, politically savvy, and well connected, she lunched with the Rockefellers, danced with the Trumans, dined with the Kennedys, and called Lady Bird Johnson by her first name. Farber had heard of her from his friends and donors in Boston. He had run into her during his early political forays in Washington. Her disarming smile and frozen bouffant were as recognizable in the political circles in Washington as in the salons of New York. Just as recognizable was her name: Mary Woodard Lasker.

  Mary Woodard was born in Watertown, Wisconsin, in 1900. Her father, Frank Woodard, was a successful small-town banker. Her mother, Sara Johnson, had emigrated from Ireland in the 1880s, worked as a saleswoman at the Carson's department store in Chicago, and ascended briskly through professional ranks to become one of the highest-paid saleswomen at the store. Salesmanship, as Lasker would later write, was "a natural talent" for Johnson. Johnson had later turned from her work at the department store to lobbying for philanthropic ventures and public projects--selling ideas instead of clothes. She was, as Lasker once put it, a woman who "could sell . . . anything that she wanted to."

  Mary Lasker's own instruction in sales began in the early 1920s, when, having graduated from Radcliffe College, she found her first job selling European paintings on commission for a gallery in New York--a cutthroat profession that involved as much social maneuvering as canny business sense. In the mid-1930s, Lasker left the gallery to start an entrepreneurial venture called Hollywood Patterns, which sold simple prefab dress designs to chain stores. Once again, good instincts crisscrossed with good timing. As women joined the workforce in increasing numbers in the 1940s, Lasker's mass-produced professional clothes found a wide market. Lasker emerged from the Depression and the war financially rejuvenated. By the late 1940s, she had grown into an extraordinarily powerful businesswoman, a permanent fixture in the firmament of New York society, a rising social star.

  In 1939, Mary Woodard met Albert Lasker, the sixty-year-old president of Lord and Thomas, an advertising firm based in Chicago. Albert Lasker, like Mary Woodard, was considered an intuitive genius in his profession. At Lord and Thomas, he had invented and perfected a new strategy of advertising that he called "salesmanship in print." A successful advertisement, Lasker contended, was not merely a conglomeration of jingles and images designed to seduce consumers into buying an object; rather, it was a masterwork of copywriting that would tell a consumer why to buy a product. Advertising was merely a carrier for information and reason, and for the public to grasp its impact, information had to be distilled into its essential elemental form. Each of Lasker's widely successful ad campaigns--for Sunkist oranges, Pepsodent toothpaste, and Lucky Strike cigarettes among many others--highlighted this strategy. In time, a variant of this idea, of advertising as a lubricant of information and of the need to distill information into elemental iconography would leave a deep and lasting impact on the cancer campaign.

  Mary and Albert had a brisk romance and a whirlwind courtship, and they were married just fifteen months after they met--Mary for the second time, Albert for the third. Mary Lasker was now forty years old. Wealthy, gracious, and enterprising, she now launched a search for her own philanthropic cause--retracing her mother's conversion from a businesswoman into a public activist.

  For Mary Lasker, this search soon turned inward, into her personal life. Three memories from her childhood and adolescence haunted her. In one, she awakes from a terrifying illness--likely a near-fatal bout of bacterial dysentery or pneumonia--febrile and confused, and overhears a family friend say to her mother that she will likely not survive: "Sara, I don't think that you will ever raise her."

  In another, she has accompanied her mother to visit her family's laundress in Watertown, Wisconsin. The woman is recovering from surgery for breast cancer--radical mastectomies performed on both breasts. Lasker enters a dark shack with a low, small cot with seven children running around and she is struck by the desolation and misery of the scene. The notion of breasts being excised to stave cancer--"Cut off?" Lasker asks her mother searchingly--puzzles and grips her. The laundress survives; "cancer," Lasker realizes, "can be cruel but it does not need to be fatal."

  In the third, she is a teenager in college, and is confined to an influenza ward during the epidemic of 1918. The lethal Spanish flu rages outside, decimating towns and cities. Lasker survives--but the flu will kill six hundred thousand Americans that year, and take nearly fifty million lives worldwide, becoming the deadliest pandemic in history.

  A common thread ran through these memories: the devastation of illness--so proximal and threatening at all times--and the occasional capacity, still unrealized, of medicine to transform lives. Lasker imagined unleashing the power of medical research to combat diseases--a power that, she felt, was still largely untapped. In 1939, the year that she met Albert, her life collided with illness again: in Wisconsin, her mother suffered a heart attack and then a stroke, leaving her paralyzed and incapacitated. Lasker wrote to the head of the American Medical Association to inquire about treatment. She was amazed--and infuriated, again--at the lack of knowledge and the unrealized potential of medicine: "I thought that was ridiculous. Other diseases could be treated . . . the sulfa drugs had come into existence. Vitamin deficiencies could be corrected, such as scurvy and pellagra. And I thought there was no good reason why you couldn't do something about stroke, because people didn't universally die of stroke . . . there must be some element that was influential."

  In 1940, after a prolonged and unsuccessful convalescence, Lasker's mother died in Watertown. For Lasker, her mother's death brought to a boil the fury and indignation that had been building within her for decades. She had found her mission. "I am opposed to heart attacks and cancer," she would later tell a reporter, "the way one is opposed to sin." Mary Lasker chose to eradicate diseases as some might eradicate sin--through evangelism. If people did not believe in the importance of a national strategy against diseases, she would convert them, using every means at her disposal.

  Her first convert was her husband. Grasping Mary's commitment to the idea, Albert Lasker became her partner, her adviser, her strategist, her coconspirator. "There are unlimited funds," he told her. "I will show you how to get them." This idea--of
transforming the landscape of American medical research using political lobbying and fund-raising at an unprecedented scale--electrified her. The Laskers were professional socialites, in the same way that one can be a professional scientist or a professional athlete; they were extraordinary networkers, lobbyists, minglers, conversers, persuaders, letter writers, cocktail party-throwers, negotiators, name-droppers, deal makers. Fund-raising--and, more important, friend-raising--was instilled in their blood, and the depth and breadth of their social connections allowed them to reach deeply into the minds--and pockets--of private donors and of the government.

  "If a toothpaste . . . deserved advertising at the rate of two or three or four million dollars a year," Mary Lasker reasoned, "then research against diseases maiming and crippling people in the United States and in the rest of the world deserved hundreds of millions of dollars." Within just a few years, she transformed, as BusinessWeek magazine once put it, into "the fairy godmother of medical research."

  The "fairy godmother" blew into the world of cancer research one morning with the force of an unexpected typhoon. In April 1943, Mary Lasker visited the office of Dr. Clarence Cook Little, the director of the American Society for the Control of Cancer in New York. Lasker was interested in finding out what exactly his society was doing to advance cancer research, and how her foundation could help.

  The visit left her cold. The society, a professional organization of doctors and a few scientists, was self-contained and moribund, an ossifying Manhattan social club. Of its small annual budget of about $250,000, it spent an even smaller smattering on research programs. Fund-raising was outsourced to an organization called the Women's Field Army, whose volunteers were not represented on the ASCC board. To the Laskers, who were accustomed to massive advertising blitzes and saturated media attention--to "salesmanship in print"--the whole effort seemed haphazard, ineffectual, stodgy, and unprofessional. Lasker was bitingly critical: "Doctors," she wrote, "are not administrators of large amounts of money. They're usually really small businessmen . . . small professional men"--men who clearly lacked a systematic vision for cancer. She made a $5,000 donation to the ASCC and promised to be back.