How to Change Your Mind

by Michael Pollan

  In an editorial accompanying Griffiths’s paper, the University of Chicago psychiatrist and drug abuse expert Harriet de Wit tried to address this tension, pointing out that the quest for experiences that “free oneself of the bounds of everyday perception and thought in a search for universal truths and enlightenment” is an abiding element of our humanity that has nevertheless “enjoyed little credibility in the mainstream scientific world.” The time had come, she suggested, for science “to recognize these extraordinary subjective experiences . . . even if they sometimes involve claims about ultimate realities that lie outside the purview of science.”

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  ROLAND GRIFFITHS might be the last scientist one would ever imagine getting mixed up with psychedelics, which surely helps explain his success in returning psychedelic research to scientific respectability. Six feet tall and rail thin, Griffiths, in his seventies, holds himself bolt upright; the only undisciplined thing about him is a thatch of white hair so dense it appears to have held his comb to a draw. At least until you get him talking about the ultimate questions, which light him up, he comes across as the ultimate straight arrow: sober, earnest, and methodical.

  Born in 1944, Griffiths grew up in El Cerrito, California, in the Bay Area, and went to Occidental College for his undergraduate education (majoring in psychology) and then on to the University of Minnesota to study psychopharmacology. At Minnesota in the late 1960s, he came under the influence of B. F. Skinner, the radical behaviorist who helped shift the focus of psychology from the exploration of inner states and subjective experience to the study of outward behavior and how it is conditioned. Behaviorism has little interest in plumbing the depths of the human psyche, but the approach proved very useful in studying behaviors like drug use and dependence, which became Griffiths’s specialty. Psychedelic drugs played no role in either his formal or his informal education. By the time Griffiths got to graduate school, Timothy Leary’s notorious psychedelic research project at Harvard had already collapsed in scandal, and “it was clear from my mentors that these were compounds that had no future.”

  In 1972, right out of graduate school, Griffiths was hired at Johns Hopkins, where he has worked ever since, making his mark as a researcher studying the mechanisms of dependence in a variety of legal and illegal drugs, including the opiates, the so-called sedative hypnotics (like Valium), nicotine, alcohol, and caffeine. Working under grants from the National Institute on Drug Abuse, Griffiths helped pioneer the sorts of experiments in which an animal, often a baboon or a rat, is presented with a lever allowing it to self-administer various drugs intravenously, a powerful tool for researchers studying reinforcement, dependence, preferences (lunch or more cocaine?), and withdrawal. The fifty-five papers he published exploring the addictive properties of caffeine transformed the field, helping us to see coffee less as a food than as a drug, and led to the listing of “caffeine withdrawal” syndrome in the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders, or DSM 5. By the time Griffiths turned fifty, in 1994, he was a scientist at the top of his game and his field.

  But that year Griffiths’s career took an unexpected turn, the result of two serendipitous introductions. The first came when a friend introduced him to Siddha Yoga. Despite his behaviorist orientation as a scientist, Griffiths had always been interested in what philosophers call phenomenology—the subjective experience of consciousness. He had tried meditation as a graduate student but found that “he couldn’t sit still without going stark-raving mad. Three minutes felt like three hours.” But when he tried it again in 1994, “something opened up for me.” He started meditating regularly, going on retreats, and working his way through a variety of Eastern spiritual traditions. He found himself drawn “deeper and deeper into this mystery.”

  Somewhere along the way, Griffiths had what he modestly describes as “a funny kind of awakening”—a mystical experience. I was surprised when Griffiths mentioned this during our first meeting in his office, so I hadn’t followed up, but even after I had gotten to know him a little better, Griffiths was still reluctant to say much more about exactly what happened and, as someone who had never had such an experience, I had trouble gaining any traction with the idea whatsoever. All he would tell me is that the experience, which took place in his meditation practice, acquainted him with “something way, way beyond a material worldview that I can’t really talk to my colleagues about, because it involves metaphors or assumptions that I’m really uncomfortable with as a scientist.”

  In time, what he was learning about “the mystery of consciousness and existence” in his meditation practice came to seem more compelling to him than his science. He began to feel somewhat alienated: “None of the people I was close to had any interest in entertaining those questions, which fell into the general category of the spiritual, and religious people I just didn’t get.

  “Here I am, a full professor, publishing like crazy, running off to important meetings, and thinking I was a fraud.” He began to lose interest in the research that had organized his whole adult life. “I could study a new sedative hypnotic, learn something new about brain receptors, be on another FDA [Food and Drug Administration] panel, go to another conference, but so what? I was more emotionally and intellectually curious about where this other path might lead. My drug research began to seem vacuous. I was going through the motions at work, much more interested in going home in the evening to meditate.” The only way he could motivate himself to continue writing grants was to think of it as a “service project” for his graduate students and postdocs.

  In the case of his caffeine research, Griffiths had been able to take his curiosity about a dimension of his own experience—why did he feel compelled to drink coffee every day?—and turn it into a productive line of scientific inquiry. But he could see no way to do that with his deepening curiosity about the dimensions of consciousness that meditation had opened up to him. “It never occurred to me there was any way to study it scientifically.” Stymied and bored, Griffiths began to entertain thoughts of quitting science and going off to an ashram in India.

  It was around this time that Bob Schuster, an old friend and colleague who had recently retired as head of the National Institute on Drug Abuse, phoned Griffiths to suggest he talk to a young man he had recently met at Esalen named Bob Jesse. Jesse had organized a small gathering of researchers, therapists, and religious scholars at the legendary Big Sur retreat center to discuss the spiritual and therapeutic potential of psychedelic drugs and how they might be rehabilitated. Jesse himself was neither a medical professional nor a scientist; he was a computer engineer, a vice president of business development at Oracle, who had made it his mission to revive the science of psychedelics—but as a tool not so much of medicine as of spiritual development.

  Griffiths had told Schuster a little about his spiritual practice and confided in him his growing discontent with conventional drug research.

  “You should talk to this guy,” Schuster told him. “They have some interesting ideas about working with entheogens,” he said. “You might have something in common.”

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  WHEN THE HISTORY of second-wave psychedelic research is written, Bob Jesse will be seen as one of a pair of scientific outsiders in America—amateurs, really, and brilliant eccentrics—who worked tirelessly, often behind the scenes, to get it off the ground. Both found their vocation in the wake of transformative psychedelic experiences that convinced them these substances had the potential to heal not only individuals but humankind as a whole and that the best path to their rehabilitation was by way of credible scientific research. In many cases, these untrained researchers dreamed up the experiments first and then found (and funded) the scientists to conduct them. Often you will find their names on the papers, usually in the last position.

  Of the two, Rick Doblin has been at it longer and is by far the more well know
n. Doblin founded the Multidisciplinary Association for Psychedelic Studies (MAPS) all the way back in the dark days of 1986—the year after MDMA was made illegal and a time when most wiser heads were convinced that restarting research into psychedelics was a cause beyond hopeless.

  Doblin, born in 1953, is a great shaggy dog with a bone; he has been lobbying to change the government’s mind about psychedelics since shortly after graduating from New College, in Florida, in 1987. After experimenting with LSD as an undergraduate, and later with MDMA, Doblin decided his calling in life was to become a psychedelic therapist. But after the banning of MDMA in 1985, that dream became unachievable without a change in federal laws and regulations, so he decided he’d better first get a doctorate in public policy at Harvard’s Kennedy School. There, he mastered the intricacies of the FDA’s drug approval process, and in his dissertation plotted the laborious path to official acceptance that psilocybin and MDMA are now following.

  Doblin is disarmingly, perhaps helplessly, candid, happy to talk openly to a reporter about his formative psychedelic experiences as well as political strategy and tactics. Like Timothy Leary, Doblin is the happiest of warriors, never not smiling and exhibiting a degree of enthusiasm for the work you wouldn’t expect from a man who has been knocking his head against the same wall for his entire adult life. Doblin works out of a somewhat Dickensian office tucked into the attic of his rambling colonial in Belmont, Massachusetts, at a desk stacked to the ceiling with precarious piles of manuscripts, journal articles, photographs, and memorabilia reaching back more than forty years. Some of the memorabilia commemorates the time early in his career when Doblin decided the best way to end sectarian strife would be to mail a group of the world’s spiritual leaders tablets of MDMA, a drug famous for its ability to break down barriers between people and kindle empathy. Around the same time, he arranged to have a thousand doses of MDMA sent to people in the Soviet military who were working on arms control negotiations with President Reagan.

  For Doblin, winning FDA approval for the medical use of psychedelics—which he believes is now in view, for both MDMA and psilocybin—is a means to a more ambitious and still more controversial end: the incorporation of psychedelics into American society and culture, not just medicine. This of course is the same winning strategy followed by the campaign to decriminalize marijuana, in which promoting the medical uses of cannabis changed the drug’s image, leading to a more general public acceptance.

  Not surprisingly, this sort of talk rankles more cautious heads in the community (Bob Jesse among them), but Rick Doblin is not one to soft-pedal his agenda or to even think about taking an interview off the record. This gets him a lot of press; how much it helps the cause is debatable. But there is no question that especially in the last several years Doblin has succeeded in getting important research approved and funded, especially in the case of MDMA, which has long been MAPS’s main focus. MAPS has sponsored several small clinical trials that have demonstrated MDMA’s value in treating post-traumatic stress disorder, or PTSD. (Doblin defines psychedelics generously, so as to include MDMA and even cannabis, even though their mechanisms of action in the brain are very different from that of the classical psychedelics.) But beyond helping those suffering with PTSD and other indications—MAPS is sponsoring a clinical study at UCLA that involves treating autistic adults with MDMA—Doblin believes fervently in the power of psychedelics to improve humankind by disclosing a spiritual dimension of consciousness we all share, regardless of our religious beliefs or lack thereof. “Mysticism,” he likes to say, “is the antidote to fundamentalism.”

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  COMPARED WITH RICK DOBLIN, Bob Jesse is a monk. There is nothing shaggy or uncareful about him. Taut, press shy, and disposed to choose his words with a pair of tweezers, Jesse, now in his fifties, prefers to do his work out of public view, and preferably from the one-room cabin where he lives by himself in the rugged hills north of San Francisco, off the grid except for a fast Internet connection.

  “Bob Jesse is like the puppeteer,” Katherine MacLean told me. MacLean is a psychologist who worked in Roland Griffiths’s lab from 2009 until 2013. “He’s the visionary guy working behind the scenes.”

  Following Jesse’s meticulous directions, I drove north from the Bay Area, eventually winding up at the end of a narrow dirt road in a county he asked me not to name. I parked at a trailhead and made my way past the “No Trespassing” signs, following a path up a hill that brought me to his picturesque mountaintop camp. I felt as if I were going to visit the wizard. The shipshape little cabin is tight for two, so Jesse has set out among the fir trees and boulders some comfortable sofas, chairs, and tables. He’s also built an outdoor kitchen and, on a shelf of rock commanding a spectacular view of the mountains, an outdoor shower, giving the camp the feeling of a house turned inside out.

  We spent the better part of an early spring day outdoors in his living room, sipping herbal tea and discussing his notably quieter campaign to restore psychedelics to respectability—a master plan in which Roland Griffiths plays a central role. “I’m a little camera shy,” he began, “so please, no pictures or recordings of any kind.”

  Jesse is a slender, compact fellow with a squarish head of closely cropped gray hair and rimless rectangular glasses that are unostentatiously stylish. Jesse seldom smiles and has some of the stiffness I associate with engineers, though occasionally he’ll surprise you with a flash of emotion he will immediately then caption: “You may have noticed that thinking about that subject made my eyes get a little watery. Let me explain why . . .” Not only does he choose his own words with great care, but he insists that you do too, so, for example, when I carelessly deployed the term “recreational use,” he stopped me in mid-sentence. “Maybe we need to reexamine that term. Typically, it is used to trivialize an experience. But why? In its literal meaning, the word ‘recreation’ implies something decidedly nontrivial. There is much more to be said, but let’s bookmark this topic for another time. Please go on.” My notes show that Jesse took our first conversation on and off the record half a dozen times.

  Jesse grew up outside Baltimore and went to Johns Hopkins, where he studied computer science and electrical engineering. For several years in his twenties, he worked for Bell Labs, commuting weekly from Baltimore to New Jersey. During this period, he came out of the closet and persuaded management to recognize the company’s first gay and lesbian employee group. (At the time, AT&T, the parent company, employed some 300,000 people.) Later, he persuaded AT&T management to fly a rainbow flag over headquarters during Gay Pride Week and send a delegation to march in the parade. This achievement formed Bob Jesse’s political education, impressing on him the value of working behind the scenes without making a lot of noise or demanding credit.

  Jesse moved to Oracle, and the Bay Area, in 1990, becoming employee number 8766—not one of the first, but early enough to have acquired a chunk of stock in the company. It wasn’t long before Oracle fielded its own contingent in San Francisco’s Gay Pride Parade, and after Jesse’s gentle prodding of senior management Oracle became one of the first Fortune 500 companies to offer benefits to the same-sex partners of its employees.

  Jesse’s curiosity about psychedelics was first piqued during a drug education unit in his high school science class. This particular class of drugs was neither physically nor psychologically addictive, he was told (correctly); his teacher went on to describe the drugs’ effects, including shifts in consciousness and visual perception that Jesse found intriguing. “I could sense there was even more here than they were telling us,” he recalled. “So I made a mental note.” But he would not be ready to see for himself what psychedelics were all about until much later. Why? He answered in the third person: “A closeted gay kid might be afraid of what might come out if he let his guard down.”

  In his twenties, while working at Bell Labs, Jesse fell in with a group of friends in Baltimore who decided, i
n a most deliberate way, to experiment with psychedelics. Someone would always remain “close to ground level” in case anyone needed help or the doorbell rang, and doses escalated gradually. It was during one of these Saturday afternoon experiments, in an apartment in Baltimore, that Jesse, twenty-five years old and having ingested a high dose of LSD, had a powerful “non-dual experience” that would prove transformative. I asked him to describe it, and after some hemming and hawing—“I hope you’ll bracket what is sensitive”—he gingerly proceeded to tell the story.

  “I was lying on my back underneath a ficus tree,” he recalls. “I knew it was going to be a strong experience. And the point came where the little I still was just started slipping away. I lost all awareness of being on the floor in an apartment in Baltimore; I couldn’t tell if my eyes were opened or closed. What opened up before me was, for lack of a better word, a space, but not our ordinary concept of space, just the pure awareness of a realm without form and void of content. And into that realm came a celestial entity, which was the emergence of the physical world. It was like the big bang, but without the boom or the blinding light. It was the birth of the physical universe. In one sense it was dramatic—maybe the most important thing that ever occurred in the history of the world—yet it just sort of happened.”

  I asked him where he was in all this.

  “I was a diffusely located observer. I was coextensive with this emergence.” Here I let him know he was losing me. Long pause. “I’m hesitating because the words are an awkward fit; words seem too constraining.” Ineffability is of course a hallmark of the mystical experience. “The awareness transcends any particular sensory modality,” he explained, unhelpfully. Was it scary? “There was no terror, only fascination and awe.” Pause. “Um, maybe a little fear.”