Life's Greatest Secret

by Matthew Cobb

  Brillouin, L., ‘Life, thermodynamics, and cybernetics’, American Scientist, vol. 37, 1949, pp. 554–68.

  Brillouin, L., Science and Information Theory, New York, Academic Press, 1956.

  Britten, R. J. and Davidson, E. H., ‘Gene regulation for higher cells: a theory’, Science, vol. 165, 1969, pp. 349–57.

  Brown, P., Sutikna, T., Morwood, M. J. et al., ‘A new small-bodied hominin from the Late Pleistocene of Flores, Indonesia’, Nature, vol. 431, 2004, pp. 1055–61.

  Brown, T. L., Making Truth: Metaphor in Science, Urbana, University of Illinois Press, 2003.

  Burian, R. M. and Gayon, J., ‘The French school of genetics: From physiological and population genetics to regulatory molecular genetics’, Annual Review of Genetics, vol. 33, 1999, pp. 313–49.

  Burkeman, O., ‘Why everything you’ve been told about evolution is wrong’, The Guardian, 19 March 2010.

  Burnet, M., Enzyme, Antigen and Virus: A Study of Macromolecular Pattern in Action, Cambridge, Cambridge University Press, 1956.

  Burnet, M., Changing Patterns: An Atypical Autobiography, London, Heinemann, 1968.

  Caetano-Anollés, G. and Seufferheld, M. J., ‘The coevolutionary roots of biochemistry and cellular organization challenge the RNA world paradigm’, Journal of Molecular Microbiology and Biotechnology, vol. 23, 2013, pp. 152–77.

  Cairns, J., ‘The autoradiography of DNA’, in Cairns, J., Stent, G. S. and Watson, J. D. (eds), Phage and the Origins of Molecular Biology, Cold Spring Harbor, Cold Spring Harbor Laboratory of Quantitative Biology, 1966, pp. 252–7.

  Cairns, J., Stent, G. S. and Watson, J. D. (eds), Phage and the Origins of Molecular Biology, Cold Spring Harbor, Cold Spring Harbor Laboratory of Quantitative Biology, 1966.

  Caldwell, P. C. and Hinshelwood, C., ‘Some considerations on autosynthesis in bacteria’, Journal of the Chemical Society, vol. 4, 1950, pp. 3156–9.

  Callaway, E., ‘The Neanderthal in the family’, Nature, vol. 507, 2014a, pp. 415–16.

  Callaway, E., ‘Geneticists tap human knockouts’, Nature, vol. 514, 2014b, p. 548.

  Cannarozzi, G., Schraudolph, N. N., Faty, M. et al., ‘A role for codon order in translation dynamics’, Cell, vol. 141, 2010, pp. 355–67.

  Carey, N., The Epigenetics Revolution: How Modern Biology is Rewriting Our Understanding of Genetics, Disease and Inheritance, London, Icon, 2011.

  Carlson, E. A., The Gene: A Critical History, New York, W. B. Saunders, 1966.

  Carlson, E. A., Genes, Radiation and Society: The Life and Work of H. J. Muller, London, Cornell University Press, 1981.

  Carlson, E. A., Mendel’s Legacy: The Origin of Classical Genetics, Cold Spring Harbor, Cold Spring Harbor Laboratory Press, 2004.

  Carroll, S. B., Brave Genius: A Scientist, a Philosopher, and Their Daring Adventures from the French Resistance to the Nobel Prize, New York, Crown, 2013.

  Caspersson, T., ‘The relations between nucleic acid and protein synthesis’, Symposia of the Society for Experimental Biology, vol. 1, 1947, pp. 127–51.

  Caspersson, T. and Schultz, J., ‘Pentose nucleotides in the cytoplasm of growing tissues’, Nature, vol. 143, 1939, pp. 602–3.

  Caspersson, T., Hammarsten, E. and Hammarsten, H., ‘Interactions of proteins and nucleic acid’, Transactions of the Faraday Society, vol. 31, 1935, pp. 367–89.

  Cavalcanti, A. R. O. and Landweber, L. F., ‘Genetic code’, Current Biology, vol. 14, 2004, p. R147.

  Cavalli-Sforza, L. L., ‘Bacterial genetics’, Annual Review of Microbiology, vol. 11, 1957, pp. 391–418.

  Chantrenne, H., ‘Information in biology’, Nature, vol. 197, 1963, pp. 27–30.

  Chargaff, E., ‘On the nucleoproteins and nucleic acids of microorganisms’, Cold Spring Harbor Symposia in Quantitative Biology, vol. 12, 1947, pp. 28–34.

  Chargaff, E., ‘Chemical specificity of nucleic acids and mechanism of their enzymatic degradation’, Experientia, vol. 6, 1950, pp. 201–9.

  Chargaff, E., ‘Some recent studies of the composition and structure of nucleic acids’, Journal of Cellular and Comparative Physiology, vol. 38 (Suppl. 1), 1951, pp. 41–59.

  Chargaff, E., ‘Base composition of desoxypentose and pentose nucleic acids in various species’, in W. D. McElroy and B. Glass (eds), A Symposium on the Chemical Basis of Heredity, Baltimore, The Johns Hopkins Press, 1957, pp. 521–7.

  Chargaff, E., Heraclitean Fire: Sketches from a Life before Nature, New York, Rockefeller University Press, 1978.

  Chargaff, E. and Vischer, E., ‘Nucleoproteins, nucleic acids, and related substances’, Annual Review of Biochemistry, vol. 17, 1948, pp. 201–26.

  Chargaff, E., Lipschitz, R., Green, C. and Hodes, M. E., ‘The composition of the desoxyribonucleic acid of salmon sperm’, Journal of Biological Chemistry, vol. 192, 1951, pp. 223–30.

  Chien, A., Edgar, D. B. and Trela, J. M., ‘Deoxyribonucleic acid polymerase from the extreme thermophile Thermus aquaticus‘, Journal of Bacteriology, vol. 127, 1976, pp. 1550–7.

  Chow, L. T., Gelinas, R. E., Broker, T. R. and Roberts, R. J., ‘An amazing sequence arrangement at the 5’ ends of adenovirus 2 messenger RNA’, Cell, vol. 12, 1977, pp. 1–8.

  Church, G. M., Gao, Y. and Kosuri, S., ‘Next-generation digital information storage in DNA’, Science, vol. 337, 2012, p. 1628.

  Clark, B. F. and Marcker, K. A., ‘The role of N-formyl-methionyl-sRNA in protein biosynthesis’, Journal of Molecular Biology, vol. 17, 1966, pp. 394–406.

  Cleland, C. E. and Copley, S. D., ‘The possibility of alternative microbial life on Earth’, International Journal of Astrobiology, vol. 4, 2005, pp. 165–73.

  Cobb, M., ‘Heredity before genetics: A history’, Nature Reviews: Genetics, vol. 7, 2006a, pp. 953–8.

  Cobb, M., The Egg and Sperm Race: The Seventeenth Century Scientists Who Unravelled the Secrets of Sex, Life and Growth, London, Free Press, 2006b. (Published in the US as Generation, New York: Bloomsbury.) Cobb, M., ‘The unclosed loop – ESF minibrains report’, EMBO Reports, vol. 12, 2011, pp. 389–91.

  Cobb, M., ‘Oswald Avery, DNA, and the transformation of biology’, Current Biology, vol. 24, 2014, pp. R55–R60.

  Cochran, W. and Crick, F. H. C., ‘Evidence for the Pauling-Corey α-helix in synthetic polypeptides’, Nature, vol. 169, 1952, pp. 234–5.

  Cochran, W., Crick, F. H. and Vand, V., ‘The structure of synthetic polypeptides. I. The transform of atoms on a helix’, Acta Crystallographica, vol. 5, 1952, pp. 581–6.

  Cohen, S. S., ‘Streptomycin and desoxyribonuclease in the study of variations in the properties of a bacterial virus’, Journal of Biological Chemistry, vol. 168, 1947, pp. 511–26.

  Cohen, S. S., ‘Alfred Ezra Mirsky, 1900–1974’, National Academy of Sciences Biographical Memoir, Washington DC, National Academies Press, 1998.

  Cohn, M., Cohen, G. N. and Monod, J., ‘L’effet inhibiteur spécifique de la methionine dans la formation de la methionine-synthase chez Escherichia coli’, Comptes rendus hebdomodaires des séances de l’Académie des sciences, vol. 236, 1953a, pp. 746–8.

  Cohn, M., Monod, J., Pollock, M. R. et al., ‘Terminology of enzyme formation’, Nature, vol. 172, 1953b, pp. 1096–7.

  Collier, J., ‘Information in biological systems’, in P. Adriaans and J. v. Benthem (eds), Handbook of the Philosophy of Science. Volume 8: Philosophy of Information, Amsterdam, Elsevier, 2008, pp. 736–87.

  Colnort-Bodet, S., ‘Pierre de Latil: La pensée artificielle’, Revue d’histoire des sciences et de leurs applications, vol. 7, 1954, p. 196.

  Comfort, N., ‘Recombinant gold’, Nature, vol. 508, 2014, pp. 176–7.

  Commoner, B., ‘Failure of the Watson-Crick theory as a chemical explanation of inheritance’ Nature, vol. 220, 1968, pp. 334–40.

  Cong, L., Ran, F. A., Cox, D. et al., ‘Multiplex genome engineering using CRISPR/Cas systems’, Science, vol. 339, 2013, pp. 819–23.

  Conway, F. and Siegelman, J., Dark Hero of the Information Age: In Search of Norbert Wiener, the Fat
her of Cybernetics, New York, Basic Books, 2005.

  Corden, J., Wasylyk, B., Buchwalder, A. et al., ‘Promoter sequences of eukaryotic protein-coding genes’, Science, vol. 209, 1980, pp. 1406–14.

  Cornelis, G., Vernochet, C., Malicorne, S. et al., ‘Retroviral envelope syncytin capture in an ancestrally diverged mammalian clade for placentation in the primitive Afrotherian tenrecs’, Proceedings of the National Academy of Sciences USA, vol. 111, 2014, pp. E4332–41.

  Corjito, S., Wardenaar, R., Colomé-Tatché, M. et al., ‘Mapping the epigenetic basis of complex traits’, Science, vol. 343, 2014, pp. 1145–8.

  Cosentino, C. and Bates, D., Feedback Control in Systems Biology, Boca Raton, CRC Press, 2012.

  Couffignal, L. (ed.), Le Concept de l’information dans la science contemporaine, Paris, Gauthier-Villars, 1965.

  Coyne, J. A., ‘The gene is dead; long live the gene’, Nature, vol. 408, 2000, pp. 26–7.

  Crabbe, J. C., Wahlsten, D. and Dudek, B. C., ‘Genetics of mouse behavior: Interactions with laboratory environment’, Science, vol. 284, 1999, pp. 1670–2.

  Creager, A. N. H., ‘Phosphorus-32 in the Phage Group: radioisotopes as historical tracers of molecular biology’, Studies in History and Philosophy of Biological and Biomedical Sciences, vol. 40, 2009, pp. 29–42.

  Creager, A. N. H. and Morgan, G. J., ‘After the double helix: Rosalind Franklin’s research on tobacco mosaic virus’, Isis, vol. 99, 2008, pp. 239–72.

  Creeth, J. M., Gulland, J. M. and Jordan, D. O., ‘Deoxypentose nucleic acids. Part III. Viscosity and streaming birefringence of solutions of the sodium salt of the deoxypentose nucleic acid of calf thymus’, Journal of the Chemical Society, vol. 1947, 1947, pp. 1141–5.

  Crick, F. H. C., ‘On degenerate templates and the adaptor hypothesis’ Unpublished note, RNA Tie Club, Wellcome Trust Library, SB/2/1/106, http://genome.wellcome.ac.uk/assets/wtx030893.pdf, 1955.

  Crick, F. H. C., ‘Nucleic acids’, Scientific American, vol. 197, 1957, pp. 188–200.

  Crick, F. H. C., ‘On protein synthesis’, Symposia of the Society for Experimental Biology, vol. 12, 1958, pp. 138–63.

  Crick, F. H. C., ‘The present position of the coding problem’, Brookhaven Symposia in Biology, vol. 12, 1959, pp. 35–9.

  Crick, F., ‘Towards the genetic code’, Scientific American, vol. 207 (3), 1962, pp. 8–16.

  Crick, F. H. C., ‘The recent excitement in the coding problem’, Progress in Nucleic Acids Research, vol. 1, 1963a, pp. 163–217.

  Crick, F. H. C., ‘On the genetic code’, Science, vol. 139, 1963b, pp. 461–4.

  Crick, F. H. C., ‘The genetic code – yesterday, today, and tomorrow’, Cold Spring Harbor Symposia on Quantitative Biology, vol. 31, 1966a, pp. 3–9.

  Crick, F. H. C., ‘Codon-anticodon pairing: the wobble hypothesis’, Journal of Molecular Biology, vol. 19, 1966b, pp. 548–55.

  Crick, F. H. C., ‘The origin of the genetic code’, Journal of Molecular Biology, vol. 38, 1968, pp. 367–79.

  Crick, F., ‘Central dogma of molecular biology’ Nature, vol. 227, 1970, pp. 561–3.

  Crick, F., ‘Split genes and RNA splicing’, Science, vol. 204, 1979, pp. 264–71.

  Crick, F., Life Itself: Its Origin and Nature, London, Macdonald, 1981.

  Crick, F., What Mad Pursuit: A Personal View of Scientific Discovery, Cambridge, MA, Basic, 1988.

  Crick, F. H. C. and Watson, J. D., ‘The complementary structure of deoxyribonucleic acid’, Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences, vol. 223, 1954, pp. 80–96.

  Crick, F. H. C., Griffith, J. S. and Orgel, L. E., ‘Codes without commas’, Proceedings of the National Academy of Sciences USA, vol. 43, 1957, pp. 416–21.

  Crick, F. H. C., Barnett, L., Brenner, S. and Watts-Tobin, R. J., ‘General nature of the genetic code for proteins’, Nature, vol. 192, 1961, pp. 1227–32.

  Crow, J. F., ‘Erwin Schrödinger and the hornless cattle problem’, Genetics, vol. 130, 1992, pp. 83–6.

  Crow, E. W. and Crow, J. F., ’100 years ago: Walter Sutton and the chromosome theory of heredity’, Genetics, vol. 160, 2002, pp. 1–4.

  Daly, M. M., Allfrey, V. G. and Mirsky, A. E., ‘Purine and pyrimidine contents of some desoxypentose nucleic acids’, The Journal of General Physiology, vol. 133, 1950, pp. 497–510.

  Danchin, E., ‘Avatars of information: towards an inclusive evolutionary synthesis’, Trends in Ecology and Evolution, vol. 28, 2013, pp. 351–8.

  Dancoff, S. M. and Quastler, H., ‘The information content and error rate of living things’, in H. Quastler (ed.), Essays on the Use of Information Theory in Biology, Urbana, University of Illinois Press, 1953, pp. 263–73.

  Davies, K., The Sequence: Inside the Race for the Human Genome, London, Phoenix, 2002.

  Davies, M., ‘W. T. Astbury, Rosie Franklin, and DNA: A memoir’, Annals of Science, vol. 47, 1990, pp. 607–18.

  Davies, P. C. W., Benner, S. A., Cleland, C. A. et al., ‘Signatures of a shadow biosphere’, Astrobiology, vol. 9, 2009, pp. 241–9.

  Davis, D. M., The Compatibility Gene, London, Allen Lane, 2013.

  Davis, J., ‘Microvenus’, Art Journal, spring 1996, pp. 70–4.

  Davis, L. and Chin, J. W., ‘Designer proteins: applications of genetic code expansion in cell biology’, Nature Reviews Molecular Cell Biology, vol. 13, 2013, pp. 168–82.

  Davis, T. H., ‘Meselsohn and Stahl: The art of DNA replication’, Proceedings of the National Academy of Sciences USA, vol. 101, 2004, pp. 17895–6.

  Daxinger, L. and Whitelaw, E., ‘Understanding transgenerational epigenetic inheritance via the gametes in mammals’, Nature Reviews Genetics, vol. 13, 2012, pp. 153–62.

  Debré, P., Jacques Monod, Paris, Flammarion, 1996.

  De Chadarevian, S., ‘Portrait of a discovery: Watson, Crick, and the Double Helix’, Isis, vol. 94, 2003, pp. 90–105.

  Deichmann, U., ‘Early responses to Avery et al.’s paper on DNA as hereditary material’, Historical Studies in the Physical and Biological Sciences, vol. 34, 2004, pp. 207–32.

  Deichmann, U., ‘Different methods and metaphysics in early molecular genetics – a case of disparity of research?’, History and Philosophy of the Life Sciences, vol. 30, 2008, pp. 53–78.

  de Latil, P., La Pensée artificielle: Introduction à la cybernétique, Paris, Gallimard, 1953.

  de Latil, P., Thinking by Machine: A Study of Cybernetics, Boston, Houghton Mifflin, 1957.

  Delbrück, M., ‘Génétique du bactériophage’, Colloques Internationaux du Centre National de la Recherche Scientifique, vol. 8, 1949, pp. 92–103.

  Delbrück, M. and Stent, G., ‘On the mechanism of DNA replication’, in W. D. McElroy and B. Glass (eds), A Symposium on the Chemical Basis of Heredity, Baltimore, The Johns Hopkins Press, 1957, pp. 699–736.

  De Lorenzo, V., ‘From the selfish gene to selfish metabolism: Revisiting the central dogma’, BioEssays, vol. 36, 2014, pp. 226–35.

  Denenberg, V. H. and Rosenberg, K. M., ‘Nongenetic transmission of information’, Nature, vol. 216, 1967, pp. 549–50.

  Di Giulio, M., ‘The origin of the genetic code in the ocean abysses: new comparisons confirm old observations’, Journal of Theoretical Biology, vol. 333, 2013a, pp. 109–16.

  Di Giulio, M., ‘The origin of the genetic code: Matter of metabolism or physicochemical determinism?’, Journal of Molecular Evolution, vol. 77, 2013b, pp. 131–3.

  Dobzhansky, T., Genetics and the Origin of Species, New York, Columbia University Press, 1941.

  Donohue, J., ‘Fragments of Chargaff’, Nature, vol. 276, 1978, pp. 133–5.

  Doolittle, W. F. and Sapienza, C., ‘Selfish genes, the phenotype paradigm and genome evolution’, Nature, vol. 284, 1980, pp. 601–3.

  Doolittle, W. F., Brunet, T. D. P., Linquist, S. and Gregory, T. R., ‘Distinguishing between “function” and “effect” in genome biology’, Genome Biology and Evolution, vol. 6, 2014, pp. 1234–7.

  Dounce, A. L., ‘Duplic
ating mechanism for peptide chain and nucleic acid synthesis’, Enzymologia, vol. 15, 1952, pp. 251–8.

  Dounce, A. L., Morrison, M. and Monty, K. J., ‘Role of nucleic acid and enzymes in peptide chain synthesis’, Nature, vol. 176, 1955, pp. 597–8.

  Doyle, R., On Beyond Living: Rhetorical Transformations of the Life Sciences, Stanford, Stanford University Press, 1997.

  Dromanraju, K. R., ‘Erwin Schrödinger and the origins of molecular biology’, Genetics, vol. 153, 1999, pp. 1071–6.

  Du, X., Wojtowicz, D., Bowers, A. A. et al., ‘The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli‘, Nucleic Acids Research, vol. 41, 2013, pp. 5965–77.

  Dubarle, D., ‘Sens philosophique et portée pratique de la cybernétique’, La Nouvelle Revue Française, vol. 10, 1953, pp. 60–85.

  Dubos, R. J., The Professor, the Institute and DNA, New York, Rockefeller University Press, 1976.

  Dudai, Y., Jan, Y. N., Byers, D. et al., ‘dunce, a mutant of Drosophila deficient in learning’, Proceedings of the National Academy of Sciences USA, vol. 73, 1976, pp. 1684–8.

  Dunn, A. R. and Hassell, J. A., ‘A novel method to map transcripts: evidence for homology between an adenovirus mRNA and discrete multiple regions of the viral genome’, Cell, vol. 12, 1977, pp. 23–36.

  Easterling, K., Walter Pitts. Cabinet, 5, http://cabinetmagazine.org/issues/5/walterpitts.php, 2001.

  Eck, R. V., ‘Non-randomness in amino-acid “alleles”’, Nature, vol. 191, 1961, pp. 1284–5.

  Eck, R. V., ‘Genetic code: emergence of a symmetrical pattern’, Science, vol. 140, 1963, pp. 477–81.

  Eddy, S. R., ‘The C-value paradox, junk DNA and ENCODE’, Current Biology, vol. 22, 2012, pp. R898–9.

  Eddy, S. R., ‘The ENCODE project: Missteps overshadowing a success’, Current Biology, vol. 23, 2013, pp. R259–61.

  Eisenhart, C., ‘Cybernetics: A new discipline’, Science, vol. 109, 1949, pp. 397–8.

  Elias, P., ‘Two famous papers’, IRE Transactions on Information Theory, vol. 4, 1958, p. 99.

  Elias, P., ‘Coding and information theory’, Reviews of Modern Physics, vol. 31, 1959, pp. 221–5.