Lethal Remedy pft-4

by Richard L Mabry

Sara looked at her watch for what must have been the tenth time in the past half hour. Where was Rip? “We’ll wait until everyone’s here to order,” Mark said. The waiter nodded, deposited drinks on the table, and walked away. The group sat in a small private dining room, centered at a table that would accommodate eight, with Mark and Sara on one side, John across from them. A fourth place setting marked the spot where Rip would sit. “I guess we’ll wait until Rip gets here to start sharing information,” Sara said, “but I’m sorry to say I don’t know a lot more than I did when we met last.” John fiddled with the silverware in front of him. “The same goes for me.” “I have a few things to-” Mark stopped as Rip hurried into the room. “Sorry to be late. It appears that my attempts to find out more about Jandramycin stirred up a hornet’s nest.” He dropped into the vacant chair and drank deeply from the glass of iced water in front of him. Sara leaned across toward him. “What happened? Are you all right?” “Yes, but no thanks to whoever drove the SUV that sideswiped me and pushed me into a concrete abutment.” Rip pulled a handkerchief from his pocket and wiped his brow. “My car will need some body work, but I managed to keep it under control. Otherwise, I’d have bounced out into the road and been broadsided by another vehicle.” “Could it have been an accident?” John asked. “I saw the SUV in my rearview mirror just before he hit me. I’m pretty sure he was aiming right at me, trying to sideswipe my car.” Mark leaned back in his chair. “So there’ve been attempts aimed at Sara and Rip. John, I guess you’ve been spared.”

  “Because I haven’t been asking around. There’s the difference.” “So who have we asked?” Rip said. “Jack Ingersoll, Carter Resnick��� “

  “The higher-ups at Jandra,” Sara added. “And, of course, there could be someone else who knows what we’re doing, someone we don’t even know about,” Mark added. “What do we do about it?” Sara asked. Mark tented his fingers under his chin. “Rip, I suppose your accident was investigated by the police.” “Yeah, they came out. Said they’d file a report, put out a bulletin to body shops. I don’t look for anything to come of it, though.” “And we know the shooting involving Sara was reported,” Mark added. “I could talk with the police and try to tie those together, see if they’re willing to investigate further.” “But that’s not likely. Right?” John said. “Not really,” Mark replied.

  “Forget it,” Rip said. Mark nodded his agreement. “So I guess we either stop digging-” “Never!” both Sara and Rip answered in unison.

  “Or be careful,” Mark said. “You started to tell us what you’ve found,” Sara said. “What was that?” “One of the guys in my law school class ended up at the FDA. He sort of owes me-I coached him through his last year-so I gave him a call. Could he get a copy of Jandra’s NDA for Jandramycin? No way. Apparently they’ve pulled some strings with the FDA and gotten it not only fast-tracked but protected from everyone but the small group that’s due to review it.” “Makes no difference,” Rip said. “The mechanism of action they quote for the drug is probably cell wall destruction, and we know that’s just a smokescreen. We need the real mechanism if we’re going to figure out how to block the late complications.” Mark nodded. “And we can’t get that from Jandra.” “Never going to happen,” Rip said. “Or from the investigators,” Mark concluded. “And I understand that we don’t have time to analyze the compound we have on hand, then do the animal experimentation to show its mechanism of action,” Sara said. Mark shook his head. “I believe we’ve tried every legal means available to get the information we need.” As she pondered that last phrase, Sara decided that maybe it was time to think outside the box. She had a couple of ideas-but she decided she’d better keep them to herself for now.

  Mark signed the bill, retrieved his American Express card, and closed the folder. “Thank you all for coming.” John dropped his napkin beside his empty coffee cup. “Thanks for dinner. It was good to throw around some ideas and share information, but I’m afraid we’re no closer to a solution of our problem than we were before we started.”

  One by one, the group pushed back their chairs and stood. Rip declined a ride with John, saying that although his car looked terrible it was still drivable. “I’ll call my insurance company in the morning and see about getting a rental while mine’s in the shop.” Mark was happy to see that Sara was the last in the group to move toward the door. He touched her on the shoulder. “I was wondering if you might like to go somewhere for a-I was about to say a drink, then I remembered-for another cup of coffee? We haven’t really had a chance to talk with each other tonight.” He could see Sara consider the offer. Her frown told him the answer before she spoke. “Mark, I like you. Under more normal circumstances, I’d say yes. But I’m really in turmoil about this whole Jandramycin thing. Until it’s settled, I’m not ready for any kind of a relationship. For now, can we just stay friends?” She smiled, obviously trying to take the sting out of her response. “Sure.

  I understand.” He fell in step beside her. “Any more strange noises in your house?” He knew it was a low blow to remind her of what her exhusband did to torment her after he left her. During Mark’s classical education he’d memorized the oft-misquoted words of John Lyly, Renaissance poet and playwright: “The rules of fair play do not apply in love and war.” On rare occasion, he’d applied that strategy in the courtroom. After all, weren’t most legal battles a form of war?

  But he’d never had occasion to use it with respect to love��� until now.

  Sara turned on the living room lights and double-locked the front door behind her. She wondered why she’d turned down Mark’s invitation to extend the evening. Did she sense a danger in letting him get too close to her? Was there something about him that triggered her response? Something John said about Mark tickled at the edge of her memory-something about his consulting for pharmaceutical companies.

  Could one of those be Jandra? She dropped her purse on the entryway table, wincing at the muted clunk it made. She unzipped it and pulled out the revolver. A Taurus Ultra-Lite-one pound of metal that could be either a harmless paperweight or an engine of death. Sara made sure that the safety was on before she swung the cylinder open and dumped the bullets into her palm. She admired the way the copper noses shone in the light from the table lamp. She tried to visualize one of them ripping through flesh, putting an end to a human life. Finally, Sara carefully reinserted the bullets one by one. She clicked the cylinder into place with an empty chamber under the hammer, re-engaged the safety, and dropped the gun into her purse. It was ready. Was she? She wouldn’t know the answer until the situation arose. And she prayed that it never would. At her computer, Sara logged on to PubMed. In the search box, she entered Jandramycin, and was surprised to find no hits. Then it dawned on her. She was looking for preliminary work, and the name, Jandramycin, had been applied only recently. She searched her memory in vain for the initial designation of the compound. She dialed Rip Pearson’s home number. “Rip, hope I didn’t wake you.” “Not at all. I was about to sink into a hot bath. That collision shook me up a bit more than I initially thought, and I’m getting a little sore.

  What’s up?” “What was it you called Jandramycin before Jandra applied that name?” “EpAm848. Does that help?” “It may. Enjoy that hot soak.”

  She rang offbefore he could ask more questions. This might be a total waste of time, but she had to try it. Back at her computer, she opened the PubMed search box, typed in “EpAm848,” then hit “enter.” There were only four citations, three of them papers with Jack as a co-author along with Bob Wolfe and some others whom she took to be Jandra research staff. She struck pay dirt with the fourth. It was a preliminary report detailing the design of a study to investigate a potential new antibiotic. She ignored the abstract that followed. It contained nothing she didn’t already know. Instead, Sara found a slip of paper and wrote down the names of the authors: Gruber H., Rohde H.

  18

  Rip watched Jack Ingersoll walk onto the general medical ward as though he o
wned it. The man was an absolute egomaniac. The words of a Carly Simon song came immediately to mind. Something about being so vain. Rip hummed a few bars under his breath while Ingersoll paused to speak with another faculty member, undoubtedly telling him how successful his presentation had been and recounting some of his experiences in Germany. “Pearson, what do you have for me?” The musky scent of a popular-and very expensive-aftershave almost overpowered Rip. Ingersoll’s white coat fairly crackled with starch. A single pen, probably a Mont Blanc, peeked from the crisply pressed breast pocket.

  The side pocket bulged ever so slightly with what Rip guessed was the latest version of smart phone. “While you were gone, we acquired two more patients with Staph luciferus infections. All have been placed on Jandramycin and seem to be responding well.” “Very well. Take me to their rooms and let me meet them. I trust you explained to them the reason for my absence.” Sure. I told them all you were on an expense-paid junket to present a paper that was probably full of fabricated data. “Yes, sir. They understand that you were an invited speaker at a prestigious international conference.” The words burned Rip’s tongue like a mouthful of scalding hot coffee, but he managed to spit them out with a straight face. The next half hour was spent meeting the patients, both of whom were indeed recovering, thanks in no small part to Jandramycin. Neither showed any evidence of side effects or complications from the treatment. Then again, it was early.

  Unless Rip could somehow find the true mechanism of action of the antibiotic and, even more important, come up with a treatment to prevent late autoimmune reactions, one of them, maybe both, might eventually be afflicted with such a problem. The two doctors stopped in the dictation room, and Ingersoll made a few brief notes on each chart. Rip knew this was more to document his presence than add anything to the treatment plan. “Any new orders?” Rip asked. “No, no.

  You’ve done well. Followed my protocol to the letter. I presume Resnick is getting the material for lab studies on a regular basis.”

  “Right. I draw the blood myself, take the tubes to your lab, knock on the door, Resnick opens it a crack, I pass them through to him, and he slams it in my face.” “I know it grates on you that you’re not allowed in there,” Ingersoll said. “But we’re dealing with a revolutionary drug, and it’s important that our data not get into the wrong hands.”

  Rip figured he’d never have a better opening than that. “But I’m your colleague, your Fellow. I’m supposed to be a part of this study, but Resnick won’t even share the mechanism of action of the drug with me.

  And it’s important, because-” Ingersoll held up a hand like a traffic policeman. “You already know the mechanism. I told you this early on.

  Jandramycin breaks down the bacterial cell wall. I can’t go into details, but there’s a great deal more data in the New Drug Application.” Which is probably a remarkable work of fiction. Rip decided to take a different tack. “You recall that Chelsea Ferguson, one of the patients in our series, was admitted with Guillain-Barre syndrome before you left.” “Terrible when that happens. Refresh my memory about her.” Rip gave Ingersoll a brief review of Chelsea’s case, ending with, “It seems to me that this could be a late consequence of Jandramycin therapy. Would you like to see her?”

  Ingersoll shook his head. “No, no. I’m sure she’s in good hands. And too much time has passed since her treatment to implicate Jandramycin in the problem. It’s undoubtedly just one of those unfortunate circumstances.” It was clear to Rip that Ingersoll wasn’t going to admit Jandramycin could be responsible for any adverse effects. There was no need to prolong the conversation. But there was one more thing he wanted to say, and he thought he’d figured the best way to say it.

  “Dr. Ingersoll,” Rip said, “I was helping Dr. Miles clean out her attic recently, and we found something you left behind when you moved out.” “Oh? I don’t recall anything being missing. It couldn’t be very important. She can just keep it.” “I’ll tell her that, although neither of us could figure why you’d move out and leave a very expensive digital recorder behind. And why was it in the attic?” Rip was sure Ingersoll flinched for just a second before the mask dropped back in place, and he said, “I don’t know what you’re talking about.”

  Bob Wolfe had been expecting the summons, but it came from a different source. Not David Patel this time. Instead, he was told that Mr. Lindberg would like to see Mr. Wolfe in his office at his earliest convenience-in other words, now. Wolfe thanked Lindberg’s secretary, hung up the phone, and turned to look out his office window. It wouldn’t hurt Lindberg to wait a few minutes. Wolfe was sure he was being called in to report on how things went in Frankfurt, and he wanted to be certain he had the answers clear in his mind. He reran the reel of the last couple of days through his mind and smiled when he could find no fault with what he’d done or the results. He buttoned his collar, cinched up his tie, and took his jacket from a hook on the back of his office door. Wolfe paused at the open door when he saw Lindberg on the phone. Lindberg’s desk faced the huge windows that gave him a spectacular view. Some people might turn their desk away from such a distraction, but Wolfe had heard Lindberg say he kept that perk visible to remind him of how hard he had to work to retain it. In a down economy, people might be fired, but Lindberg was apparently determined to be the one doing the firing, not the one on the other end. Lindberg’s conversation was animated, to say the least. “I don’t care how you do it, but I want those mock-ups on my desk tomorrow.

  Jandramycin is the drug that’s going to save this company, and that won’t happen if no one knows about it. I want those ads ready for the front part of every major medical journal in the U.S. I want them to hit at the same time our reps are knocking on doctors’ doors to tell them about our wonder drug. One hundred percent success against the worst infections in history, with absolutely no side effects.” Wolfe faintly heard the murmur of words rattling forth from the phone when Lindberg broke in. “No, you can’t have more time. The FDA is moving this thing forward triple speed, and you don’t want to know how we managed to get that done. When they give their approval-and they will-I want those ads ready to roll with the next issue. Is that clear?” Apparently it didn’t matter whether it was clear, because Lindberg slammed down the phone without waiting for an answer. Wolfe tapped on the doorframe. “You wanted to see me, Steve?” Lindberg swiveled his chair around and in that split second managed to go from hard-nosed boss to jovial colleague. “Bob, come in. Sorry to keep you waiting.” He waved at one of the chairs across the desk from him.

  “Have a seat.” Wolfe pulled up a chair but decided to let Lindberg take the conversational lead. He didn’t have to wait long. “Tell me about the meeting in Frankfurt.” “Huge attendance, representatives from the U.S., the UK, Germany, France, Belgium-” “Okay, it was well attended. And our people had a booth where we reminded people of all the great products we have and told them we are coming out with a blockbuster. And so forth. You know what I want to hear.” Not much question there. Wolfe decided to be equally direct. “Ingersoll toed the company line perfectly. I stayed up all night before his presentation reviewing his slides, and they were perfect. Figures matched the ones we sent to the FDA in our new drug app. Conclusions in line with ours, including the lack of adverse reactions.” Lindberg nodded. “And-” “And the Q amp;A ended with him being asked if he was aware of any complications associated with Jandramycin. He parroted back what we gave him.” Wolfe smiled, remembering the way he’d reminded Ingersoll who was buttering his bread. But there was no need to mention that to Lindberg. Such actions were expected. He figured the marketing director had done similar things in his time, and probably a lot worse. “Now to another part of our problem. We’ve had no more calls from that snoopy Dr. Miles, but I understand she’s still convinced Jandramycin is responsible for a number of severe late complications in some of the patients receiving it. Now that you’re back from enjoying sauerbraten and beer, why don’t you contact your source and get an update on th
at situation? And let me know what you find out.” Lindberg rose and extended his hand, as close to a “thanks for a job well done” as Wolfe expected to receive. Before he was out the door, Wolfe heard Lindberg on the phone once more. “What do you mean, our reps can’t get in to see the doctors? Tell them to bring lunch for the staff. Hang around with them while they eat. I’ve never known a doctor who wouldn’t drift back and nosh a bit. That’s when-”

  “How are you today?” Sara plastered a smile on her face as she approached Chelsea Ferguson’s bed. For a change, the girl’s mother was not at the bedside. “Your mother not here?” Chelsea’s reply was so weak Sara had to ask her to repeat it. “My sister’s sick. Mom kept her home from school and had to stay with her.” “No problem. If you need anything, ring for the nurse. They’ll be right here for you.” Sara flipped open the chart. “How are you doing after the immune-I mean, that medicine we gave you the other day?” “Not much different.”

  Chelsea’s lower lip trembled. A tiny tear formed at the corner of one eye. “I��� I still can’t move my legs. And my arms are weak.” Sara pulled a reflex hammer from the pocket of her white coat and checked Chelsea. No reflexes in the legs, and definitely weakened responses in the arms. The immune globulin was reported to work most of the time in cases of severe GBS. But so far it hadn’t seemed to help. There must be something different about the syndrome that Jandramycin triggered.

  And she had no idea what that difference was. “Well, we have a few more tricks up our sleeve. I’ll see you again this evening when I make rounds. Meanwhile, you keep your chin up.” Chelsea nodded weakly, then turned her face to the wall. Sara eased from the room, feeling lower than she’d ever felt as a physician. God, I absolutely don’t know where to go from here. Got any suggestions?

  Lillian Goodman paused outside the treatment room door. This time she was well aware of who was inside, but still she hesitated to enter. John was getting his daily IV dose of Jandramycin. She held up her hand to knock, then dropped it to her side. Would John appreciate some company during the time he received the IV? Or would he prefer to be alone? This is silly. I’m just visiting a friend. She tapped on the door. “Yes?” Good enough. Lillian entered and closed the door behind her. She tried to put a smile in her voice as she approached the treatment table where John lay. “How are you?” “Not too bad.” He held up the arm that wasn’t receiving the IV and wiggled his fingers. “My hand is pretty much back to normal. No redness. No swelling. Not even a little tenderness. Rip thinks it’s healing fine, and I agree. So the magic medicine is doing its thing, even against the superbug.” The words hung in the air as they both considered the possible late consequences from the drug now running into John’s veins. Lillian tried to find words to change the subject, but they wouldn’t come.