Blood Matters
Page 34
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enzyme deficiencies, Jewish diseases and, [>]–[>], [>]
epilepsy, [>], [>], [>], [>]–[>], [>] n, [>] n
estrogen, [>], [>]
Etcoff, Nancy, [>]–[>]
eugenics, [>]–[>], [>], [>], [>], [>]
EuroDNA, [>]
euthanasia
Huntington’s disease and, [>], [>]
in Nazi Germany, [>]–[>], [>], [>]
exercise/physical activity, [>]–[>], [>], [>], [>] n, [>] n, [>] n
exon, defined, [>]
eye color, [>]–[>]
Faerman, Marina, [>]–[>], [>]–[>]
familial dysautonomia, [>], [>], [>], [>] n
family cancer syndrome. see cancer family syndrome
family information services, [>]–[>], [>] n
Family TreeDNA, [>], [>]–[>]
Fanconi’s anemia, [>], [>], [>]–[>]
fetal hemoglobin, [>]–[>]
fibromyalgia, [>]–[>]
folic acid, [>]
Food and Drug Administration (FDA), [>], [>], [>]
FORCE (Facing Our Risk of Cancer Empowered), [>]–[>]
forced sterilization, [>], [>], [>], [>]
forensics, [>]–[>]
Foucault, Michel, [>]
founder effect, [>]–[>]
Ashkenazi Jews and, [>]–[>], [>], [>], [>]–[>]
avoiding, [>]
Cohanim oral tradition/genetic markers and, [>]–[>], [>], [>]–[>], [>], [>], [>], [>]–[>], [>], [>] n
heterozygote advantage and, [>]–[>]
Lemba oral tradition and, [>]–[>], [>] n
nature of, [>]–[>]
ten lost tribes of Israel and, [>]–[>]
fragile-child syndrome, [>]–[>]
framing effect, in medical decision making, [>]–[>]
Friedman, Sue, [>]–[>]
frontal lobes, [>]–[>]
Frudakis, Anthony, [>], [>], [>]
Furies, The (Hobhouse), [>]–[>]
Galton, Francis, [>]–[>], [>], [>]
gangliosides, [>]
Garber, Judy, [>]–[>]
Gaucher’s disease, [>], [>], [>], [>], [>], [>]
Gellhorn, Martha, [>]–[>]
Gelsinger, Jesse, [>], [>]–[>]
genealogy, [>], [>]. see also genetic ancestry tests
gene expression, [>]–[>]
gene flow, [>]–[>]
Genelex, [>]
gene pools, alteration of, [>]–[>]
gene sequences, [>], [>], [>]–[>]
gene therapy, [>], [>]–[>], [>], [>] n
genetic ancestry tests, [>]–[>], [>]–[>], [>]–[>], [>] n
genetic code, [>]
genetic counseling, [>], [>]–[>]
counselor qualifications, [>]
Dor Yeshorim program and, [>]–[>], [>]–[>], [>]
economics and, [>]–[>], [>]
happiness, psychology of, [>]–[>]
Huntington’s disease and, [>], [>]
nondirective, [>]–[>], [>]
posttest, [>]–[>]
prenatal, [>]–[>], [>]
preventive surgery and, [>]–[>], [>], [>]
for previvors, [>]–[>]
genetic drift, [>]–[>], [>], [>], [>]–[>], [>]–[>], [>], [>]–[>], [>]
genetic experiments
mink domestication, [>]–[>]
mouse domestication, [>]–[>]
rat domestication, [>]–[>], [>]–[>]
silver-fox domestication, [>]–[>], [>]
wolf domestication, [>], [>], [>]
genetic heritage studies, [>]–[>]
sample size in, [>]
time estimates in, [>]–[>]
genetic mapping, [>]
genetics-based medicine. see also cancer family syndrome; personalized medicine
adrenoleukodystrophy, [>], [>]–[>], [>] n
Amish and, [>], [>], [>], [>]
“bubble boy” disease and, [>], [>], [>]
DNA samples in, [>]–[>]
glutaric aciduria type 1 (GA1), [>]–[>], [>]–[>], [>]
maple syrup disease and, [>]–[>], [>], [>], [>], [>] n, [>] n
Old Order Mennonites and, [>]–[>], [>], [>], [>]
seizure disorder and, [>]–[>], [>]–[>]
genetic signatures, [>]–[>], [>], [>]–[>]
genetic testing, see also prenatal screening
ancestry, [>]–[>], [>]–[>], [>]–[>], [>] n
on ancient human remains, [>]–[>]
Dor Yeshorim program, [>]–[>], [>]–[>], [>]
for gene mutations, [>]–[>], [>], [>]–[>], [>] n
Jewish attitudes toward, [>]
newborn genetic screening, [>]–[>]
population-based screening, [>]–[>]
predictive, [>], [>]–[>], [>]–[>], [>]–[>], [>] n, [>] n
preimplantation genetic diagnosis (PGD), [>], [>], [>], [>], [>], [>], [>]–[>], [>], [>] n
gene transfer, [>]
genome, [>], [>], [>]
components of, [>]–[>]
defined, [>]
mapping, [>]–[>], [>], [>]
Germany
Nazi, [>]–[>], [>]
Rhine Valley, [>]
germ-plasm, [>]
Gessen, Aaron, [>]
Gessen, Arnold, [>]
Gessen, Ilya, [>]
Gessen, Keith, [>]–[>]
Ghate, Sumedha, [>]–[>], [>], [>]
glutaric aciduria type 1 (GA1), [>]–[>], [>]–[>], [>]
glycogen storage disease Type I, [>], [>]
Gotti, Victoria, [>]
Green Bay, Wisconsin, cancer family syndrome in, [>]–[>], [>]
Greenspan, Bennett, [>]–[>]
Gritsenko, Inga, [>]–[>], [>]
Gross, Heinrich, [>]–[>], [>]
Gross, Johann, [>]–[>], [>], [>] n
guilt, about passing on mutations, [>]
Hadassah hospital (Israel), [>]–[>], [>], [>], [>]
hair samples, [>]
Hammer, Michael, [>], [>], [>], [>]
Handelin, Barbara, [>], [>]–[>], [>]–[>], [>]–[>]
haplotypes
Cohen modal, [>]–[>]
defined, [>]
mitochondrial DNA and, [>]
happiness, psychology of, [>]–[>], [>] n
Harvard University, [>]
Hasidic community
dates before marriage and, [>]
matchmaking in, [>]–[>], [>]–[>], [>]–[>], [>]
health insurance, [>]
heart disease, [>]–[>], [>], [>], [>]–[>] n
Hehmeyer, Charles, [>], [>]
hemoglobin studies, [>]–[>]
hemophilia, [>], [>]–[>]
hereditary nonpolyposis colorectal cancer, [>]–[>], [>]–[>] n
heroin addiction, [>]
heterozygosity, [>]–[>], [>], [>]
Hirschsprung’s disease, [>], [>]–[>], [>]–[>] n
Hitler, Adolf, [>], [>]–[>]
HIV, [>]–[>], [>]–[>]
Hobhouse, Janet, [>]–[>]
Holland, BRCA1 gene mutations in, [>]–[>]
homozygosity, [>], [>], [>], [>] n
homozygous, defined, [>]
Hôpital Necker-Enfants Malades (Paris), [>]
hormone-replacement therapy, [>], [>]–[>], [>]
host population, [>], [>]–[>]
human geneticists, [>]–[>], [>], [>], [>], [>], [>], [>], [>]
Human Genome Project, [>]
Human Mutation, [>]
Huntington, George, [>]
Huntington’s disease, [>], [>]–[>], [>], [>], [>]–[>] n
attitudes toward being tested for, [>]–[>], [>]–[>], [>]–[>] n
CAG repeats in, [>]–[>], [>], [>]
genetic counseling and, [>], [>]
impact of testing for, [>]–[>]
predictive testing for, [>], [>]–[>], [>]–[>], [>]–[>], [>] n
symptoms of, [>]–[>], [>]–[>], [>]–[>], [>]
true dominance and, [>]–[>], [>] n
&
nbsp; Huntington Society of Canada, [>]
hypertension
in genetic experiments, [>]–[>]
as result of surgical menopause, [>]
hypnotizability, [>]–[>]
hysterectomy, [>], [>], [>] n
Icelanders, [>], [>]
identical by descent, [>]
inbreeding, [>], [>], [>]. see also closed groups
India, family balancing in, [>]
infanticide, [>], [>]
infertility, [>]
information lovers, [>]
insurance companies, [>], [>]
intelligence
Jewish diseases and, [>]–[>], [>] n
selection for, [>]
intermarriage
gene flow and, [>]–[>]
resistance to, [>]
intersex newborns, [>]–[>], [>] n
in vitro fertilization, [>], [>], [>], [>]–[>], [>], [>]–[>]
Israel
ancient DNA studies, [>]–[>]
attitudes toward being tested for hereditary illness, [>]–[>]
deaf community in, [>]
genetic studies in, [>]–[>], [>]–[>], [>]–[>], [>], [>], [>], [>], [>]
ten lost tribes of, [>]–[>]
Jacob, [>]
Jacobs, Joseph, [>]
Jewish diseases. See also Ashkenazi Jews; breast/ovarian cancer-gene mutations
Canavan, [>], [>], [>], [>]
defining, [>]
Dor Yeshorim program and, [>]–[>], [>]–[>], [>]
founder effect and, [>]–[>]
Gaucher’s disease, [>], [>], [>], [>], [>], [>]
genetic drift as cause of, [>]–[>]
genetic studies on women, [>]
incidence of genetic diseases, [>]
intelligence and, [>]–[>], [>] n
matchmaking and, [>]–[>]
mutation in connexin 26 gene, [>]
Niemann-Pick, [>], [>], [>], [>]
selective advantage and, [>]–[>], [>]–[>], [>]
Tay-Sachs. see Tay-Sachs
Kahneman, Daniel, [>], [>]–[>]
Katzenstein, Howard, [>], [>]–[>], [>]–[>]
Kazy, Zoltán, [>]
Kharlamova, Anastasia, [>]–[>]
Khazars, [>]–[>]
Kingsbrook Jewish Medical Center (Brooklyn, New York), [>]–[>], [>]
Köszegi, Botond, [>]
Kuliev, Anver, [>]–[>], [>]–[>]
Kurdish Jews, [>]–[>], [>] n
Laboratory of Behavioral Neurogenomics, [>]–[>]
Laibson, David, [>]–[>], [>]–[>]
Lancaster General Hospital (Pennsylvania), [>], [>]
laryngeal cancer, [>]
Law for the Prevention of Genetically Diseased Offspring, [>]
Law of Return, [>]
Leahy, John, [>]–[>]
Lee, Derrick Todd, [>]
Lemba oral tradition, [>]–[>], [>] n
leprosy, [>], [>] n
leukemia, [>], [>]
Levi (son of Jacob), [>]
Levites, [>]–[>], [>] n
libido, loss of, [>]–[>], [>], [>]–[>]
life insurance, [>]
Lingua Franca, [>]–[>]
lipid-storage diseases, Jewish diseases as, [>]–[>], [>]–[>]
Little People of America, [>]
liver transplants, [>]
logical memory, [>]
Lorenzo’s Oil, [>], [>]–[>], [>] n
low-fat diet, [>], [>]
lucene, [>]–[>]
lung cancer, [>], [>] n
Lykken, David, [>]–[>]
Lynch, Henry T., [>]–[>], [>]–[>] n
Lynch, Jean, [>], [>]
Lynch syndrome, [>]–[>], [>], [>]–[>] n
malaria, [>], [>], [>]
malignant melanoma, [>]
mammography, limitations of, [>]
maple syrup disease, [>]–[>], [>], [>], [>], [>] n, [>] n
Markel, Arkady, [>]–[>], [>]
marker tests, [>]
marriage counseling, [>]–[>]
mastectomy
preventive, [>], [>]–[>], [>]–[>], [>], [>]–[>], [>], [>], [>]–[>], [>], [>], [>], [>]–[>], [>], [>]–[>], [>]–[>], [>] n
matchmaking, [>]–[>]
Dor Yeshorim program and, [>]–[>]
effectiveness of, [>]–[>]
Hasidic community and, [>]–[>], [>]–[>], [>]–[>], [>]
Kingsbrook Jewish Medical Center (Brooklyn, New York), [>]–[>], [>]
Orthodox Jews and, [>]–[>], [>]–[>]
premarital testing and, [>]–[>], [>]
matrimonial cancer dynasties, [>]–[>]
McGinn, Colin, [>]–[>], [>]
McKusick, Victor, [>]
medical decision making, [>]–[>]
medications
adverse reactions to, [>], [>], [>]–[>] n
antidepressants, [>]–[>], [>], [>]
certification for specific purposes, [>]
chemotherapy, [>], [>]–[>], [>], [>], [>]
drug-approval process, [>]
for HIV/AIDS, [>]–[>]
hormone-replacement therapy, [>], [>]–[>], [>]
melanoma, malignant, [>]
memory loss, [>]
Mendelian inheritance, defined, [>]
Mendelian Inheritance in Man (McKusick), [>]
Mendelian laws, [>], [>]–[>], [>]
Mennonites. see Old Order Mennonites
menopause, early surgical, [>]–[>], [>]–[>], [>]–[>], [>]–[>], [>] n
menstruation, delaying onset of, [>], [>] n
mental retardation
genetic causes of, [>]–[>], [>], [>] n
seizure disorders and, [>]
metabolic derangement, [>]–[>]
MHL1, [>]
microcephalic, [>]
Milgram obedience experiment, [>]
Miró, Joan, [>], [>]
miscarriage, [>]
mitochondrial DNA, [>], [>], [>], [>], [>], [>], [>], [>], [>]
mitochondrial haplotypes, [>]
Modern Orthodox, [>]–[>]
molecular anthropology, [>]–[>], [>], [>]–[>]
monitors, [>]–[>], [>] n
monoamine oxidase A (MAOA), [>]–[>], [>]
morphine, [>]–[>]
mortality risk, [>]–[>]
Morton, Caroline, [>], [>]
Morton, Holmes, [>]–[>], [>]–[>], [>]–[>]
Amish and, [>], [>]–[>], [>]
Clinic for Special Children (Strasburg, Pennsylvania), [>]–[>], [>]–[>], [>], [>]–[>], [>], [>]
newborn genetic screening and, [>]–[>]
Moser, Hugo, [>], [>]–[>]
Moses, [>], [>]
mother-daughter relationships, [>]–[>], [>]–[>]
mouse domestication, [>]–[>], [>] n
MRI screening, [>], [>]–[>], [>]–[>], [>], [>]
MSH2, [>]
Mucolipidosis Type IV, [>]
muscle myopathy, [>]
muscular atrophy, [>]–[>]
muscular dystrophy, [>]–[>]
mutation frequency, [>]
mutation mechanism, [>], [>]
Myriad, [>]–[>]
Narod, Stephen, [>]
Nash, Adam, [>]
National Cancer Institute, [>]
National Center for Biotechnology Information, [>]
National Institutes of Health (NIH), [>], [>]
nationalism, [>]
Native Americans, [>]–[>]
natural assessments, [>]
natural selection, [>]–[>], [>]–[>]
Nazi Germany, [>], [>]–[>], [>]
negative eugenics, [>]
neuroticism, [>], [>], [>]
neurotransmitters, [>], [>]
newborns
genetic screening, [>]–[>]
intersex, [>]–[>], [>]
New England Journal of Medicine, [>]
New York Times, [>]–[>]
Niemann-Pick, [>], [>], [>], [>]
nipples, [>]–[>], [>]–[>]
nondirective genetic counseling, [>]–[>], [>]
nonsyndromic deafness, [>]
Northern Ontario Hungtington Disease Resource Centre (Canada), [>]–[>]
novelty-seeking gene, [>]–[>], [>], [>]
Odone, Augusto, [>]
Odone, Lorenzo, [>]–[>]
Old Order Mennonites, [>]–[>], [>]
maple syrup disease and, [>]–[>], [>], [>], [>] n
muscle myopathy and, [>]
oocytes, [>], [>]
oophorectomy, [>], [>], [>]–[>], [>]–[>], [>], [>], [>]–[>], [>]–[>], [>]–[>], [>], [>]–[>], [>], [>]–[>], [>]–[>] n
opiates, [>]
Oppenheim, Ariella, [>], [>]–[>], [>]–[>]
ornithine transcarbamylase deficiency, [>]
Orthodox Jews, [>]
dates before marriage and, [>]
dietary limitations, [>]
matchmaking and, [>]–[>], [>]–[>]
Modern Orthodox, [>], [>]–[>]
Tay-Sachs among, [>], [>]
osteoporosis, [>], [>], [>], [>]
ovarian cancer. see also breast/ovarian cancer-gene mutations
BRCA1 and BRCA2 role in, [>]–[>