Cancerland
Page 33
religion
conception and
IVF and
poetry related to
sacrifice in
shame and
stem cell research and
remission
replication
angiogenesis and
of cells
of research
reprogramming
research. See also specific topics
abortions related to
complexity of
income in
on Laetrile
molecules related to
motivation for
by patients
pieces for
replication of
risks from
slowness of
on Yeats
research hospitals
research institutes
resistance
to AZT
Summers and
retinitis pigmentosa
retroviruses
AIDS as
leukemia related to
review board
Reynolds, Karen
Reynolds, Tim
Richards, Layla
Risk (game)
risks
in clinical trials
genes and
from research
from STAMP
Rituxan
Roh Moo-hyun
Röntgen, Wilhelm
Rorvik, David
Rosenberg, Steven
Rowley, Janet
Ryan, Celine
Ryu Young-joon
sacrifice
safety, from crime
Saks Fifth Avenue department store
Sanger, Fred
sarcoma
drug resistance and
Scadden, Kathy
Scadden, Margaret
schistosome worms
schistosomiasis
Schmidt, Benno, Sr.
Schofield, Raymond
science
of blood
collaboration in
confirmation in
creativity and
discovery from
ethics of
faith in
families and
fraud in
genome
government and
hope of
of HSCI
limitations and
medicine compared to
Occam’s razor in
power from
pseudoscience
reductionism
regulation of
“revolution” in
skin cell /iPSC
society and
step-by-step process of
stories of
urgency of
scientific progress
scientists
competition among
creative perseverance of
egos of
as explorers
families of
teachers of
screening
genetic
Seed, Brian
self-blame
The Selfish Gene (Dawkins)
Semmelwies, Ignaz
Seoul National University. See South Korea
serums
animal
sexism
sexual activity
shame, religion and
sheep
Sherwin, Steven
Shirk, Stephen
sickle-cell anemia
side effects
of chemotherapy
of interventions
of radiation therapy
SIDS. See sudden infant death syndrome
Silver, Lee
Simches Research Center
single gene mutations
skepticism
skin cell /iPSC science
social cues
social life
The Society of Genes (Lercher and Yanai)
Solid Tumor Autologous Marrow Program (STAMP)
South Korea
ethics in
human embryo cloning in
investigation in
mad cow disease and
replication and
speculation about
technique in
space race
Spanish flu pandemic of 1918–19
specialties
exams for
in medical school
technologies and
sports
STAMP. See Solid Tumor Autologous Marrow Program
standard of care
Stanford University
stem cell clinics
stem cell research
breakthrough in
competition in
complexity of
on diabetes
experiments in
fetal and embryonic
funding for
human pluripotent stem cells
religion and
of Schofield
Summers and
of Yamanaka
stem cells. See also blood stem cells; bone marrow stem cells; Harvard Stem Cell Institute; human embryonic stem (ES) cells; human pluripotent stem cells
beta cells from
features of
leukemia and
mouse embryonic
regeneration of
resilience of
transplants of
Steptoe, Patrick
STI571
Stoker, Bram
stomach cancer
stroke
sudden infant death syndrome (SIDS)
suffering
from AIDS
endurance of
self-blame for
Sullivan, Johnny
Summers, Lawrence
personality of
stem cell research and
surgeons
surgeries
for lung cancer
for malignancies
modern origins of
odors in
radical mastectomy
trauma of
Sykes, David
symptoms
CML and
syphilis
T cells
Allison and
Anaplastic Large Cell Lymphoma of
antigen receptors and
CAR T cells
Chimeric antigen receptors for
CRISPR-Cas9 and
modification of
remission and
TALENs for
TALENs. See Transcription activator-like effector nucleases
Tasmanian devil
Taxol
teachers, of scientists
teams. See also collaboration
technologies
Temple, Sally
teratomas
TGCA. See The Cancer Genome Atlas Project
thalidomide
therapy. See also specific topics
cells as
Thomas, E. Donnall “Don”
Thomas, Lewis
Thomson, James
“thought experiment”
thymus
Till, James
tissues
tobacco smoking
Buerger’s disease from
deaths and
pseudoscience and
tolerance
of self
Torok-Storb, Beverly
totipotent
Transcription activator-like effector nucleases (TALENs)
transfusions
blood typing for
transplants. See also autologous transplants; bone marrow transplants
of blood stem cells
HDC/ABMT
immune system and
standard of care
of stem cells
trauma
of surgeries
treatments
custom-tailored
of HIV
limitations of
understanding for
Tuskegee Study
Type 2 diabetes
Type I diabetes
&nbs
p; understanding
challenge of
in evidence-based medicine
hope and
for treatments
vaccines
schistosomiasis and
VAMP. See vincristine, amethopterin, methotrexate, prednisone
vampires
Varmus, Harold
Vellucci, Alfred
Venter, Craig
veterinarian
Vetter, David
vinblastine. See ABVD
vincristine, amethopterin, methotrexate, prednisone (VAMP)
viral infections
virology
viruses. See also retroviruses
adenovirus
altered polio-cold
in chickens
Epstein-Barr
“Friend”
HPV
receptor genes and
Wagers, Amy
Wagner-Jaureg, Julius
Walker, Bruce
War on Cancer
Warren, John Collins
Washington, George
Watergate
Watson, James
“Watson” (artificial intelligence)
Weissman, Irving
West, Michael
Whitehead, Emily
Wicker, Roger
Wilmut, Ian
Wimmer, Eckard
women
World War II
x-rays
Yamanaka, Shinya
Yanai, Itai
Yeats, William Butler
Zanjani, Esmail
zebrafish
Zinder, Norton
Zon, Leonard
ABOUT THE AUTHORS
DAVID SCADDEN, M.D., is the Gerald and Darlene Jordan Professor of Medicine at Harvard University. Currently a hematologist/oncologist and director of the Center for Regenerative Medicine at the Massachusetts General Hospital, he cofounded and codirects the Harvard Stem Cell Institute and is Chairman and Professor of the Harvard University Department of Stem Cell and Regenerative Biology. Dr. Scadden is a member of the National Academy of Medicine, the American Academy of Arts and Sciences, the Board of External Experts for the National Heart, Lung and Blood Institute and a former member of the National Cancer Institute’s Board of Scientific Counselors. He lives in Boston.
As part of a team of journalists from Newsday, MICHAEL D’ANTONIO won the Pulitzer Prize for his reporting before going on to write many acclaimed books, including The Truth About Trump and A Consequential President. He has also written for Esquire, The New York Times Magazine, and Sports Illustrated. He lives in Miller Place, New York. You can sign up for email updates here.
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CONTENTS
Title Page
Copyright Notice
Dedication
Epigraph
INTRODUCTION
1. DAWN OF THE BIOLOGICAL AGE
2. SEEING CANCER
3. CANCERLAND
4. CHEMICALS IN CONVERSATION
5. STEM CELLS AND A RENEWABLE YOU
6. SNUPPY THE HOUND AND IPSCS
7. PROVOKING A RESPONSE
8. GENE HACKING
9. FROM GORY TO GLORY
POSTSCRIPT: SCIENCE IN THE FUTURE TENSE
Note
Acknowledgments
Bibliography
Index
About the Authors
Copyright
AUTHOR’S NOTE: THIS IS A TRUE STORY, THOUGH SOME NAMES AND DETAILS HAVE BEEN CHANGED.
THOMAS DUNNE BOOKS.
An imprint of St. Martin’s Press.
CANCERLAND. Copyright © 2018 by David Scadden and Michael D’Antonio. All rights reserved. For information, address St. Martin’s Press, 175 Fifth Avenue, New York, N.Y. 10010.
www.thomasdunnebooks.com
www.stmartins.com
Cover design by Ervin Serrano
Cover photograph: lab coats © plainpicture / Cultura / Monty Rakusen
The Library of Congress Cataloging-in-Publication Data is available upon request
ISBN 978-1-250-09275-5 (hardcover)
ISBN 978-1-250-09277-9 (ebook)
eISBN 9781250092779
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First Edition: July 2018
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